The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages.

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Autores principales: Yunlong Yang, Patrik Andersson, Kayoko Hosaka, Yin Zhang, Renhai Cao, Hideki Iwamoto, Xiaojuan Yang, Masaki Nakamura, Jian Wang, Rujie Zhuang, Hiromasa Morikawa, Yuan Xue, Harald Braun, Rudi Beyaert, Nilesh Samani, Susumu Nakae, Emily Hams, Steen Dissing, Padraic G. Fallon, Robert Langer, Yihai Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b73ba97163914ee29b8d9b9ffa3e8e81
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spelling oai:doaj.org-article:b73ba97163914ee29b8d9b9ffa3e8e812021-12-02T14:40:16ZThe PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages10.1038/ncomms113852041-1723https://doaj.org/article/b73ba97163914ee29b8d9b9ffa3e8e812016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11385https://doaj.org/toc/2041-1723Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages.Yunlong YangPatrik AnderssonKayoko HosakaYin ZhangRenhai CaoHideki IwamotoXiaojuan YangMasaki NakamuraJian WangRujie ZhuangHiromasa MorikawaYuan XueHarald BraunRudi BeyaertNilesh SamaniSusumu NakaeEmily HamsSteen DissingPadraic G. FallonRobert LangerYihai CaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yunlong Yang
Patrik Andersson
Kayoko Hosaka
Yin Zhang
Renhai Cao
Hideki Iwamoto
Xiaojuan Yang
Masaki Nakamura
Jian Wang
Rujie Zhuang
Hiromasa Morikawa
Yuan Xue
Harald Braun
Rudi Beyaert
Nilesh Samani
Susumu Nakae
Emily Hams
Steen Dissing
Padraic G. Fallon
Robert Langer
Yihai Cao
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
description Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages.
format article
author Yunlong Yang
Patrik Andersson
Kayoko Hosaka
Yin Zhang
Renhai Cao
Hideki Iwamoto
Xiaojuan Yang
Masaki Nakamura
Jian Wang
Rujie Zhuang
Hiromasa Morikawa
Yuan Xue
Harald Braun
Rudi Beyaert
Nilesh Samani
Susumu Nakae
Emily Hams
Steen Dissing
Padraic G. Fallon
Robert Langer
Yihai Cao
author_facet Yunlong Yang
Patrik Andersson
Kayoko Hosaka
Yin Zhang
Renhai Cao
Hideki Iwamoto
Xiaojuan Yang
Masaki Nakamura
Jian Wang
Rujie Zhuang
Hiromasa Morikawa
Yuan Xue
Harald Braun
Rudi Beyaert
Nilesh Samani
Susumu Nakae
Emily Hams
Steen Dissing
Padraic G. Fallon
Robert Langer
Yihai Cao
author_sort Yunlong Yang
title The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
title_short The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
title_full The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
title_fullStr The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
title_full_unstemmed The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
title_sort pdgf-bb-sox7 axis-modulated il-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b73ba97163914ee29b8d9b9ffa3e8e81
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