Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

Complex traits are often influenced by genetic and non-genetic factors (such as environmental exposures), which are themselves interconnected. Here, the authors develop a method for disentangling genotype–covariate correlation and interaction, and investigate their effects on estimating statistical...

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Bibliographic Details
Main Authors: Guiyan Ni, Julius van der Werf, Xuan Zhou, Elina Hyppönen, Naomi R. Wray, S. Hong Lee
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/b73da63376ad4ac8b1df5ee607da5804
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