Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

Importin superfamily member IPO13 mediates nuclear transport bidirectionally. Here the authors delineate the transcriptome of wild-type and IPO13-knockout mouse embryonic stem cells, revealing IPO13’s key role in the oxidative stress response through targeted transport of specific transcription fact...

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Autores principales: K. A. Gajewska, H. Lescesen, M. Ramialison, K. M. Wagstaff, D. A. Jans
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b73e2860ff77442a8c82e2e76349fef2
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Sumario:Importin superfamily member IPO13 mediates nuclear transport bidirectionally. Here the authors delineate the transcriptome of wild-type and IPO13-knockout mouse embryonic stem cells, revealing IPO13’s key role in the oxidative stress response through targeted transport of specific transcription factors.