2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance

The overexpression of heat shock proteins (HSPs) in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments, inducing thermoresistance and thus diminishing the treatment efficacy. Here, we report a distinct “non-inhibitor involvement” strategy to address this issue...

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Autores principales:	Jianrong Wu, Xiaojun Cai, Gareth R. Williams, Zheying Meng, Weijuan Zou, Li Yao, Bing Hu, Yu Chen, Yuanyi Zheng
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Antimonene Heat shock proteins Photothermal therapy Glucose oxidase Calcium carbonate Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b73e4ca9f5854dfbaa6a4df24258c6ef
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spelling	oai:doaj.org-article:b73e4ca9f5854dfbaa6a4df24258c6ef2021-11-28T04:35:13Z2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance2452-199X10.1016/j.bioactmat.2021.08.018https://doaj.org/article/b73e4ca9f5854dfbaa6a4df24258c6ef2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003947https://doaj.org/toc/2452-199XThe overexpression of heat shock proteins (HSPs) in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments, inducing thermoresistance and thus diminishing the treatment efficacy. Here, we report a distinct “non-inhibitor involvement” strategy to address this issue through engineering a calcium-based nanocatalyst (G/A@CaCO3-PEG). The constructed nanocatalyst consists of calcium carbonate (CaCO3)-supported glucose oxidase (GOD) and 2D antimonene quantum dots (AQDs), with further surface modification by lipid bilayers and polyethylene glycol (PEG). The engineered G/A@CaCO3-PEG nanocatalyst features prolonged blood circulation, which is stable at neutral pH but rapidly degrades under mildly acidic tumor microenvironment, resulting in rapid release of drug cargo in the tumor microenvironment. The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate (ATP) and subsequent down-regulation of HSP expression. This effect then augments the therapeutic efficacy of photothermal hyperthermia induced by 2D AQDs upon irradiation with near-infrared light as assisted by reversing the cancer cells’ thermoresistance. Consequently, synergistic antineoplastic effects can be achieved via low-temperature photothermal therapy. Systematic in vitro and in vivo evaluations have demonstrated that G/A@CaCO3-PEG nanocatalysts feature potent antitumor activity with a high tumor-inhibition rate (83.92%). This work thus paves an effective way for augmenting the hyperthermia-based tumor treatments via restriction of the ATP supply.Jianrong WuXiaojun CaiGareth R. WilliamsZheying MengWeijuan ZouLi YaoBing HuYu ChenYuanyi ZhengKeAi Communications Co., Ltd.articleAntimoneneHeat shock proteinsPhotothermal therapyGlucose oxidaseCalcium carbonateMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 295-305 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimonene Heat shock proteins Photothermal therapy Glucose oxidase Calcium carbonate Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Antimonene Heat shock proteins Photothermal therapy Glucose oxidase Calcium carbonate Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Jianrong Wu Xiaojun Cai Gareth R. Williams Zheying Meng Weijuan Zou Li Yao Bing Hu Yu Chen Yuanyi Zheng 2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
description	The overexpression of heat shock proteins (HSPs) in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments, inducing thermoresistance and thus diminishing the treatment efficacy. Here, we report a distinct “non-inhibitor involvement” strategy to address this issue through engineering a calcium-based nanocatalyst (G/A@CaCO3-PEG). The constructed nanocatalyst consists of calcium carbonate (CaCO3)-supported glucose oxidase (GOD) and 2D antimonene quantum dots (AQDs), with further surface modification by lipid bilayers and polyethylene glycol (PEG). The engineered G/A@CaCO3-PEG nanocatalyst features prolonged blood circulation, which is stable at neutral pH but rapidly degrades under mildly acidic tumor microenvironment, resulting in rapid release of drug cargo in the tumor microenvironment. The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate (ATP) and subsequent down-regulation of HSP expression. This effect then augments the therapeutic efficacy of photothermal hyperthermia induced by 2D AQDs upon irradiation with near-infrared light as assisted by reversing the cancer cells’ thermoresistance. Consequently, synergistic antineoplastic effects can be achieved via low-temperature photothermal therapy. Systematic in vitro and in vivo evaluations have demonstrated that G/A@CaCO3-PEG nanocatalysts feature potent antitumor activity with a high tumor-inhibition rate (83.92%). This work thus paves an effective way for augmenting the hyperthermia-based tumor treatments via restriction of the ATP supply.
format	article
author	Jianrong Wu Xiaojun Cai Gareth R. Williams Zheying Meng Weijuan Zou Li Yao Bing Hu Yu Chen Yuanyi Zheng
author_facet	Jianrong Wu Xiaojun Cai Gareth R. Williams Zheying Meng Weijuan Zou Li Yao Bing Hu Yu Chen Yuanyi Zheng
author_sort	Jianrong Wu
title	2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
title_short	2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
title_full	2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
title_fullStr	2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
title_full_unstemmed	2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
title_sort	2d antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/b73e4ca9f5854dfbaa6a4df24258c6ef
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2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance

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