Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)

Aim. To determine the frequencies of alleles and genotypes of polymorphic marker rs7903146 of the TCF7L2 gene in latent autoimmune diabetes in adults (LADA) and healthy individuals. The aims of the study were also to compare the distribution of alleles and genotypes and to explore the association wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Iuliia V. Silko, Tatiana V. Nikonova, Olga N. Ivanova, Svetlana M. Stepanova, Marina V. Shestakova, Ivan I. Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	diabetes mellitus latent autoimmune diabetes of adults lada rs7903146 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/b73fff3fdd724c5cb00400530d5d7354
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b73fff3fdd724c5cb00400530d5d7354
record_format	dspace
spelling	oai:doaj.org-article:b73fff3fdd724c5cb00400530d5d73542021-11-14T09:00:20ZAssociation of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)2072-03512072-037810.14341/DM2003418-21https://doaj.org/article/b73fff3fdd724c5cb00400530d5d73542016-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7819https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To determine the frequencies of alleles and genotypes of polymorphic marker rs7903146 of the TCF7L2 gene in latent autoimmune diabetes in adults (LADA) and healthy individuals. The aims of the study were also to compare the distribution of alleles and genotypes and to explore the association with the development of LADA.Materials and methods. A total of 96 patients (46 females and 50 males) with LADA and 201 healthy individuals were examined. A quantitative determination of autoantibodies GADA, ICA, IA-2A and ZnT8 in the serum of LADA patients was performed. All patients underwent genotyping of rs7903146 of the TCF7L2 genes.Results. There was an increased frequency of the T allele and genotype T+ of marker rs7903146 of the TCF7L2 gene in patients with LADA with low concentrations of autoantibodies compared to a group of patients with high concentrations and with controls. We observed significant associations of the T allele and genotype T+ with LADA in patients with low concentrations of autoantibodies [p = 0.02; odds ratio (OR) = 1.85; 95% confidence interval (CI) = 1.10–3.13 and p = 0.04; OR = 2.14; 95% CI = 1.01–4.53 for the T allele and genotype T+, respectively).Conclusion. The results of the study suggest that LADA patients with low concentrations of autoantibodies have a genetically pre-determined similarity with patients with type 2 diabetes.Iuliia V. SilkoTatiana V. NikonovaOlga N. IvanovaSvetlana M. StepanovaMarina V. ShestakovaIvan I. DedovEndocrinology Research Centrearticlediabetes mellituslatent autoimmune diabetes of adultsladars7903146tcf7l2Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 3, Pp 199-203 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus latent autoimmune diabetes of adults lada rs7903146 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus latent autoimmune diabetes of adults lada rs7903146 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627 Iuliia V. Silko Tatiana V. Nikonova Olga N. Ivanova Svetlana M. Stepanova Marina V. Shestakova Ivan I. Dedov Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
description	Aim. To determine the frequencies of alleles and genotypes of polymorphic marker rs7903146 of the TCF7L2 gene in latent autoimmune diabetes in adults (LADA) and healthy individuals. The aims of the study were also to compare the distribution of alleles and genotypes and to explore the association with the development of LADA.Materials and methods. A total of 96 patients (46 females and 50 males) with LADA and 201 healthy individuals were examined. A quantitative determination of autoantibodies GADA, ICA, IA-2A and ZnT8 in the serum of LADA patients was performed. All patients underwent genotyping of rs7903146 of the TCF7L2 genes.Results. There was an increased frequency of the T allele and genotype T+ of marker rs7903146 of the TCF7L2 gene in patients with LADA with low concentrations of autoantibodies compared to a group of patients with high concentrations and with controls. We observed significant associations of the T allele and genotype T+ with LADA in patients with low concentrations of autoantibodies [p = 0.02; odds ratio (OR) = 1.85; 95% confidence interval (CI) = 1.10–3.13 and p = 0.04; OR = 2.14; 95% CI = 1.01–4.53 for the T allele and genotype T+, respectively).Conclusion. The results of the study suggest that LADA patients with low concentrations of autoantibodies have a genetically pre-determined similarity with patients with type 2 diabetes.
format	article
author	Iuliia V. Silko Tatiana V. Nikonova Olga N. Ivanova Svetlana M. Stepanova Marina V. Shestakova Ivan I. Dedov
author_facet	Iuliia V. Silko Tatiana V. Nikonova Olga N. Ivanova Svetlana M. Stepanova Marina V. Shestakova Ivan I. Dedov
author_sort	Iuliia V. Silko
title	Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
title_short	Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
title_full	Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
title_fullStr	Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
title_full_unstemmed	Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)
title_sort	association of polymorphism rs7903146 gene tcf7l2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (lada)
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/b73fff3fdd724c5cb00400530d5d7354
work_keys_str_mv	AT iuliiavsilko associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada AT tatianavnikonova associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada AT olganivanova associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada AT svetlanamstepanova associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada AT marinavshestakova associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada AT ivanidedov associationofpolymorphismrs7903146genetcf7l2withlowconcentrationsofautoantibodiesinlatentautoimmunediabetesofadultslada
_version_	1718429552226598912

Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)

Ejemplares similares