Concerted localization-resets precede YAP-dependent transcription

The transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene transcription, the authors show that YAP-dependen...

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Autores principales:	J. Matthew Franklin, Rajarshi P. Ghosh, Quanming Shi, Michael P. Reddick, Jan T. Liphardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b74055e5260d4791ba53349afa233f25
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spelling	oai:doaj.org-article:b74055e5260d4791ba53349afa233f252021-12-02T17:41:08ZConcerted localization-resets precede YAP-dependent transcription10.1038/s41467-020-18368-x2041-1723https://doaj.org/article/b74055e5260d4791ba53349afa233f252020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18368-xhttps://doaj.org/toc/2041-1723The transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene transcription, the authors show that YAP-dependent signalling is encoded through rapid and concerted changes in the nucleo-cytoplasmic distribution of YAP.J. Matthew FranklinRajarshi P. GhoshQuanming ShiMichael P. ReddickJan T. LiphardtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Matthew Franklin Rajarshi P. Ghosh Quanming Shi Michael P. Reddick Jan T. Liphardt Concerted localization-resets precede YAP-dependent transcription
description	The transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene transcription, the authors show that YAP-dependent signalling is encoded through rapid and concerted changes in the nucleo-cytoplasmic distribution of YAP.
format	article
author	J. Matthew Franklin Rajarshi P. Ghosh Quanming Shi Michael P. Reddick Jan T. Liphardt
author_facet	J. Matthew Franklin Rajarshi P. Ghosh Quanming Shi Michael P. Reddick Jan T. Liphardt
author_sort	J. Matthew Franklin
title	Concerted localization-resets precede YAP-dependent transcription
title_short	Concerted localization-resets precede YAP-dependent transcription
title_full	Concerted localization-resets precede YAP-dependent transcription
title_fullStr	Concerted localization-resets precede YAP-dependent transcription
title_full_unstemmed	Concerted localization-resets precede YAP-dependent transcription
title_sort	concerted localization-resets precede yap-dependent transcription
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b74055e5260d4791ba53349afa233f25
work_keys_str_mv	AT jmatthewfranklin concertedlocalizationresetsprecedeyapdependenttranscription AT rajarshipghosh concertedlocalizationresetsprecedeyapdependenttranscription AT quanmingshi concertedlocalizationresetsprecedeyapdependenttranscription AT michaelpreddick concertedlocalizationresetsprecedeyapdependenttranscription AT jantliphardt concertedlocalizationresetsprecedeyapdependenttranscription
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Concerted localization-resets precede YAP-dependent transcription

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