Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 inducers. This study provides insights into the design...
Guardado en:
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b744783a8c5b4f278122faa72d2167f4 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:b744783a8c5b4f278122faa72d2167f4 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:b744783a8c5b4f278122faa72d2167f42021-12-02T15:55:21ZMolecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism10.1038/s42003-021-02100-62399-3642https://doaj.org/article/b744783a8c5b4f278122faa72d2167f42021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02100-6https://doaj.org/toc/2399-3642Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 inducers. This study provides insights into the design of Nrf2 activators targeting the Keap1-Nrf2 interaction.Yuta HorieTakafumi SuzukiJin InoueTatsuro IsoGeoffrey WellsTerry W. MooreTsunehiro MizushimaAlbena T. Dinkova-KostovaTakuma KasaiTakashi KameiSeizo KoshibaMasayuki YamamotoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Yuta Horie Takafumi Suzuki Jin Inoue Tatsuro Iso Geoffrey Wells Terry W. Moore Tsunehiro Mizushima Albena T. Dinkova-Kostova Takuma Kasai Takashi Kamei Seizo Koshiba Masayuki Yamamoto Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
description |
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 inducers. This study provides insights into the design of Nrf2 activators targeting the Keap1-Nrf2 interaction. |
format |
article |
author |
Yuta Horie Takafumi Suzuki Jin Inoue Tatsuro Iso Geoffrey Wells Terry W. Moore Tsunehiro Mizushima Albena T. Dinkova-Kostova Takuma Kasai Takashi Kamei Seizo Koshiba Masayuki Yamamoto |
author_facet |
Yuta Horie Takafumi Suzuki Jin Inoue Tatsuro Iso Geoffrey Wells Terry W. Moore Tsunehiro Mizushima Albena T. Dinkova-Kostova Takuma Kasai Takashi Kamei Seizo Koshiba Masayuki Yamamoto |
author_sort |
Yuta Horie |
title |
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
title_short |
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
title_full |
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
title_fullStr |
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
title_full_unstemmed |
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism |
title_sort |
molecular basis for the disruption of keap1–nrf2 interaction via hinge & latch mechanism |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/b744783a8c5b4f278122faa72d2167f4 |
work_keys_str_mv |
AT yutahorie molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT takafumisuzuki molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT jininoue molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT tatsuroiso molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT geoffreywells molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT terrywmoore molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT tsunehiromizushima molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT albenatdinkovakostova molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT takumakasai molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT takashikamei molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT seizokoshiba molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism AT masayukiyamamoto molecularbasisforthedisruptionofkeap1nrf2interactionviahingelatchmechanism |
_version_ |
1718385415100039168 |