Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis
Ochratoxin A(OTA) is considered to be one of the most important contaminants of food and feed worldwide. The liver is one of key target organs for OTA to exert its toxic effects. Due to current lifestyle and diet, nonalcoholic fatty liver disease (NAFLD) has been the most common liver disease. To ex...
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oai:doaj.org-article:b74733d14f964bbc8a2d6186af0a8b0f2021-11-25T19:08:57ZOchratoxin A Induces Steatosis via PPARγ-CD36 Axis10.3390/toxins131108022072-6651https://doaj.org/article/b74733d14f964bbc8a2d6186af0a8b0f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/802https://doaj.org/toc/2072-6651Ochratoxin A(OTA) is considered to be one of the most important contaminants of food and feed worldwide. The liver is one of key target organs for OTA to exert its toxic effects. Due to current lifestyle and diet, nonalcoholic fatty liver disease (NAFLD) has been the most common liver disease. To examine the potential effect of OTA on hepatic lipid metabolism and NAFLD, C57BL/6 male mice received 1 mg/kg OTA by gavage daily. Compared with controls, OTA increased lipid deposition and TG accumulation in mouse livers. In vitro OTA treatment also promoted lipid droplets accumulation in primary hepatocytes and HepG2 cells. Mechanistically, OTA prevented PPARγ degradation by reducing the interaction between PPARγ and its E3 ligase SIAH2, which led to activation of PPARγ signaling pathway. Furthermore, downregulation or inhibition of CD36, a known of PPARγ, alleviated OTA-induced lipid droplets deposition and TG accumulation. Therefore, OTA induces hepatic steatosis via PPARγ-CD36 axis, suggesting that OTA has an impact on liver lipid metabolism and may contribute to the development of metabolic diseases.Qian-Wen ZhengXu-Fen DingHui-Jun CaoQian-Zhi NiBing ZhuNing MaFeng-Kun ZhangYi-Kang WangSheng XuTian-Wei ChenJi XiaXiao-Song QiuDian-Zhen YuDong XieJing-Jing LiMDPI AGarticlefatty liver diseaselipid metabolismOTAPPARMedicineRENToxins, Vol 13, Iss 802, p 802 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
fatty liver disease lipid metabolism OTA PPAR Medicine R |
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fatty liver disease lipid metabolism OTA PPAR Medicine R Qian-Wen Zheng Xu-Fen Ding Hui-Jun Cao Qian-Zhi Ni Bing Zhu Ning Ma Feng-Kun Zhang Yi-Kang Wang Sheng Xu Tian-Wei Chen Ji Xia Xiao-Song Qiu Dian-Zhen Yu Dong Xie Jing-Jing Li Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| description |
Ochratoxin A(OTA) is considered to be one of the most important contaminants of food and feed worldwide. The liver is one of key target organs for OTA to exert its toxic effects. Due to current lifestyle and diet, nonalcoholic fatty liver disease (NAFLD) has been the most common liver disease. To examine the potential effect of OTA on hepatic lipid metabolism and NAFLD, C57BL/6 male mice received 1 mg/kg OTA by gavage daily. Compared with controls, OTA increased lipid deposition and TG accumulation in mouse livers. In vitro OTA treatment also promoted lipid droplets accumulation in primary hepatocytes and HepG2 cells. Mechanistically, OTA prevented PPARγ degradation by reducing the interaction between PPARγ and its E3 ligase SIAH2, which led to activation of PPARγ signaling pathway. Furthermore, downregulation or inhibition of CD36, a known of PPARγ, alleviated OTA-induced lipid droplets deposition and TG accumulation. Therefore, OTA induces hepatic steatosis via PPARγ-CD36 axis, suggesting that OTA has an impact on liver lipid metabolism and may contribute to the development of metabolic diseases. |
| format |
article |
| author |
Qian-Wen Zheng Xu-Fen Ding Hui-Jun Cao Qian-Zhi Ni Bing Zhu Ning Ma Feng-Kun Zhang Yi-Kang Wang Sheng Xu Tian-Wei Chen Ji Xia Xiao-Song Qiu Dian-Zhen Yu Dong Xie Jing-Jing Li |
| author_facet |
Qian-Wen Zheng Xu-Fen Ding Hui-Jun Cao Qian-Zhi Ni Bing Zhu Ning Ma Feng-Kun Zhang Yi-Kang Wang Sheng Xu Tian-Wei Chen Ji Xia Xiao-Song Qiu Dian-Zhen Yu Dong Xie Jing-Jing Li |
| author_sort |
Qian-Wen Zheng |
| title |
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| title_short |
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| title_full |
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| title_fullStr |
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| title_full_unstemmed |
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis |
| title_sort |
ochratoxin a induces steatosis via pparγ-cd36 axis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b74733d14f964bbc8a2d6186af0a8b0f |
| work_keys_str_mv |
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