A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by enhancing fatty acid uptake of brown fat.

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Detalles Bibliográficos
Autores principales:	Lingling Shu, Ruby L. C. Hoo, Xiaoping Wu, Yong Pan, Ida P. C. Lee, Lai Yee Cheong, Stefan R Bornstein, Xianglu Rong, Jiao Guo, Aimin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7476498d71d4c13b9c088b8d15a882a
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spelling	oai:doaj.org-article:b7476498d71d4c13b9c088b8d15a882a2021-12-02T17:06:30ZA-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes10.1038/ncomms141472041-1723https://doaj.org/article/b7476498d71d4c13b9c088b8d15a882a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14147https://doaj.org/toc/2041-1723The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by enhancing fatty acid uptake of brown fat.Lingling ShuRuby L. C. HooXiaoping WuYong PanIda P. C. LeeLai Yee CheongStefan R BornsteinXianglu RongJiao GuoAimin XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingling Shu Ruby L. C. Hoo Xiaoping Wu Yong Pan Ida P. C. Lee Lai Yee Cheong Stefan R Bornstein Xianglu Rong Jiao Guo Aimin Xu A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
description	The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by enhancing fatty acid uptake of brown fat.
format	article
author	Lingling Shu Ruby L. C. Hoo Xiaoping Wu Yong Pan Ida P. C. Lee Lai Yee Cheong Stefan R Bornstein Xianglu Rong Jiao Guo Aimin Xu
author_facet	Lingling Shu Ruby L. C. Hoo Xiaoping Wu Yong Pan Ida P. C. Lee Lai Yee Cheong Stefan R Bornstein Xianglu Rong Jiao Guo Aimin Xu
author_sort	Lingling Shu
title	A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
title_short	A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
title_full	A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
title_fullStr	A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
title_full_unstemmed	A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
title_sort	a-fabp mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b7476498d71d4c13b9c088b8d15a882a
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A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

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