A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by enhancing fatty acid uptake of brown fat.

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Detalles Bibliográficos
Autores principales: Lingling Shu, Ruby L. C. Hoo, Xiaoping Wu, Yong Pan, Ida P. C. Lee, Lai Yee Cheong, Stefan R Bornstein, Xianglu Rong, Jiao Guo, Aimin Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/b7476498d71d4c13b9c088b8d15a882a
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