Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.

<h4>Background</h4>Non-adherence to anti tuberculosis treatment is one of the crucial challenges in improving tuberculosis cure-rates and reducing further healthcare costs. The poor adherence to anti-tuberculosis treatment among patients with tuberculosis is a major problem in Ethiopia....

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Autores principales:	Akilew Awoke Adane, Kefyalew Addis Alene, Digsu Negese Koye, Berihun Megabiaw Zeleke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b74911a8e0224ec69ebce2dc18ab617e
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spelling	oai:doaj.org-article:b74911a8e0224ec69ebce2dc18ab617e2021-11-18T08:47:31ZNon-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.1932-620310.1371/journal.pone.0078791https://doaj.org/article/b74911a8e0224ec69ebce2dc18ab617e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244364/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Non-adherence to anti tuberculosis treatment is one of the crucial challenges in improving tuberculosis cure-rates and reducing further healthcare costs. The poor adherence to anti-tuberculosis treatment among patients with tuberculosis is a major problem in Ethiopia. Hence, this study assessed level of non-adherence to anti-tuberculosis therapy and associated factors among patients with tuberculosis in northwest Ethiopia.<h4>Methods</h4>An institution based cross-sectional survey was conducted among tuberculosis patients who were following anti-tuberculosis treatment in North Gondar zone from February 20--March 30, 2013. Data were collected by trained data collectors using a structured and pre-tested questionnaire. Data were entered to EPI INFO version 3.5.3 and analyzed using statistical package for social sciences (SPSS) version 20. Multiple logistic regressions were fitted to identify associations and to control potential confounding variables. Odds ratio (OR) with 95% confidence interval was calculated and p-values<0.05 were considered statistically significant.<h4>Results</h4>A total of 280 tuberculosis patients were interviewed; 55.7% were males and nearly three quarters (72.5%) were urban dwellers. The overall non-adherence for the last one month and the last four days before the survey were 10% and 13.6% respectively. Non-adherence was high if the patients had forgetfulness (AOR 7.04, 95% CI 1.40-35.13), is on the continuation phase of chemotherapy (AOR: 6.95, 95% CI 1.81-26.73), had symptoms of tuberculosis during the interview (AOR: 4.29, 95% CI 1.53-12.03), and had co-infection with HIV (AOR: 4.06, 95% CI 1.70-9.70).<h4>Conclusions</h4>Non-adherence to anti-tuberculosis treatment was high. Forgetfulness, being in the continuation phases of chemotherapy, having symptoms of tuberculosis during the interview, and co-infected with HIV were significantly associated with non-adherence to anti-tuberculosis therapy. Special attention on adherence counseling should be given to symptomatic patients, TB/HIV co-infected patients, and those in the continuation phase of the tuberculosis therapy.Akilew Awoke AdaneKefyalew Addis AleneDigsu Negese KoyeBerihun Megabiaw ZelekePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78791 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akilew Awoke Adane Kefyalew Addis Alene Digsu Negese Koye Berihun Megabiaw Zeleke Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
description	<h4>Background</h4>Non-adherence to anti tuberculosis treatment is one of the crucial challenges in improving tuberculosis cure-rates and reducing further healthcare costs. The poor adherence to anti-tuberculosis treatment among patients with tuberculosis is a major problem in Ethiopia. Hence, this study assessed level of non-adherence to anti-tuberculosis therapy and associated factors among patients with tuberculosis in northwest Ethiopia.<h4>Methods</h4>An institution based cross-sectional survey was conducted among tuberculosis patients who were following anti-tuberculosis treatment in North Gondar zone from February 20--March 30, 2013. Data were collected by trained data collectors using a structured and pre-tested questionnaire. Data were entered to EPI INFO version 3.5.3 and analyzed using statistical package for social sciences (SPSS) version 20. Multiple logistic regressions were fitted to identify associations and to control potential confounding variables. Odds ratio (OR) with 95% confidence interval was calculated and p-values<0.05 were considered statistically significant.<h4>Results</h4>A total of 280 tuberculosis patients were interviewed; 55.7% were males and nearly three quarters (72.5%) were urban dwellers. The overall non-adherence for the last one month and the last four days before the survey were 10% and 13.6% respectively. Non-adherence was high if the patients had forgetfulness (AOR 7.04, 95% CI 1.40-35.13), is on the continuation phase of chemotherapy (AOR: 6.95, 95% CI 1.81-26.73), had symptoms of tuberculosis during the interview (AOR: 4.29, 95% CI 1.53-12.03), and had co-infection with HIV (AOR: 4.06, 95% CI 1.70-9.70).<h4>Conclusions</h4>Non-adherence to anti-tuberculosis treatment was high. Forgetfulness, being in the continuation phases of chemotherapy, having symptoms of tuberculosis during the interview, and co-infected with HIV were significantly associated with non-adherence to anti-tuberculosis therapy. Special attention on adherence counseling should be given to symptomatic patients, TB/HIV co-infected patients, and those in the continuation phase of the tuberculosis therapy.
format	article
author	Akilew Awoke Adane Kefyalew Addis Alene Digsu Negese Koye Berihun Megabiaw Zeleke
author_facet	Akilew Awoke Adane Kefyalew Addis Alene Digsu Negese Koye Berihun Megabiaw Zeleke
author_sort	Akilew Awoke Adane
title	Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
title_short	Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
title_full	Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
title_fullStr	Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
title_full_unstemmed	Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
title_sort	non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b74911a8e0224ec69ebce2dc18ab617e
work_keys_str_mv	AT akilewawokeadane nonadherencetoantituberculosistreatmentanddeterminantfactorsamongpatientswithtuberculosisinnorthwestethiopia AT kefyalewaddisalene nonadherencetoantituberculosistreatmentanddeterminantfactorsamongpatientswithtuberculosisinnorthwestethiopia AT digsunegesekoye nonadherencetoantituberculosistreatmentanddeterminantfactorsamongpatientswithtuberculosisinnorthwestethiopia AT berihunmegabiawzeleke nonadherencetoantituberculosistreatmentanddeterminantfactorsamongpatientswithtuberculosisinnorthwestethiopia
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Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.

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