High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action

Well-documented vital signs are key in the prediction of sepsis in low- and middle-income countries. We determined prevalence, associated factors, and outcomes of positive blood culture sepsis in premature neonates at Bugando Medical Centre Mwanza, Tanzania. Temperature, oxygen saturation, heart rat...

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Autores principales:	Delfina R. Msanga, Fatema Parpia, Eveline T. Konje, Adolfine Hokororo, Stephen E. Mshana
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	preterm vital signs neonatal sepsis mortality Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/b74a3a210a194b1a9ae254b042f54a9d
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spelling	oai:doaj.org-article:b74a3a210a194b1a9ae254b042f54a9d2021-11-25T17:14:45ZHigh Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action10.3390/children81110372227-9067https://doaj.org/article/b74a3a210a194b1a9ae254b042f54a9d2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1037https://doaj.org/toc/2227-9067Well-documented vital signs are key in the prediction of sepsis in low- and middle-income countries. We determined prevalence, associated factors, and outcomes of positive blood culture sepsis in premature neonates at Bugando Medical Centre Mwanza, Tanzania. Temperature, oxygen saturation, heart rate, respiratory rate, and random blood glucose were repeatedly recorded at admission, 8 h, and 24 h in all 250 neonates enrolled. Clinical and microbiological data were collected from patient records followed by descriptive data analysis. The mean age of the neonates was 3 ± 5.2 days, with the majority (90%) aged <10 days. The prevalence of positive blood culture sepsis was 21.2% (95% CI: 16.1–26.2). The fluctuation of the random blood glucose (RBG) (aOR = 1.34, 95% CI: (1.07–1.67), <i>p</i> = 0.010), low oxygen saturation (aOR = 0.94, 95% CI: (0.88–0.99), <i>p</i> = 0.031), premature rupture of membrane aOR = 4.28, 95% CI: (1.71–10.71), <i>p</i> = 0.002), gestational age < 34 weeks (aOR = 2.73, 95% CI: (1.20–6.24), <i>p</i> = 0.017), and home delivery (aOR = 3.90, 95% CI: (1.07–14.19), <i>p</i> = 0.039) independently predicted positive blood culture. Significantly more deaths were recorded in neonates with a positive blood culture than those with a negative blood culture (32.1% vs. 5.1%, <i>p</i> < 0.001). In limited-resource settings, clinicians should use the vital signs and clinical information to initiate timely sepsis treatment among preterm neonates to prevent deaths and other morbidities.Delfina R. MsangaFatema ParpiaEveline T. KonjeAdolfine HokororoStephen E. MshanaMDPI AGarticlepretermvital signsneonatal sepsismortalityPediatricsRJ1-570ENChildren, Vol 8, Iss 1037, p 1037 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preterm vital signs neonatal sepsis mortality Pediatrics RJ1-570
spellingShingle	preterm vital signs neonatal sepsis mortality Pediatrics RJ1-570 Delfina R. Msanga Fatema Parpia Eveline T. Konje Adolfine Hokororo Stephen E. Mshana High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
description	Well-documented vital signs are key in the prediction of sepsis in low- and middle-income countries. We determined prevalence, associated factors, and outcomes of positive blood culture sepsis in premature neonates at Bugando Medical Centre Mwanza, Tanzania. Temperature, oxygen saturation, heart rate, respiratory rate, and random blood glucose were repeatedly recorded at admission, 8 h, and 24 h in all 250 neonates enrolled. Clinical and microbiological data were collected from patient records followed by descriptive data analysis. The mean age of the neonates was 3 ± 5.2 days, with the majority (90%) aged <10 days. The prevalence of positive blood culture sepsis was 21.2% (95% CI: 16.1–26.2). The fluctuation of the random blood glucose (RBG) (aOR = 1.34, 95% CI: (1.07–1.67), <i>p</i> = 0.010), low oxygen saturation (aOR = 0.94, 95% CI: (0.88–0.99), <i>p</i> = 0.031), premature rupture of membrane aOR = 4.28, 95% CI: (1.71–10.71), <i>p</i> = 0.002), gestational age < 34 weeks (aOR = 2.73, 95% CI: (1.20–6.24), <i>p</i> = 0.017), and home delivery (aOR = 3.90, 95% CI: (1.07–14.19), <i>p</i> = 0.039) independently predicted positive blood culture. Significantly more deaths were recorded in neonates with a positive blood culture than those with a negative blood culture (32.1% vs. 5.1%, <i>p</i> < 0.001). In limited-resource settings, clinicians should use the vital signs and clinical information to initiate timely sepsis treatment among preterm neonates to prevent deaths and other morbidities.
format	article
author	Delfina R. Msanga Fatema Parpia Eveline T. Konje Adolfine Hokororo Stephen E. Mshana
author_facet	Delfina R. Msanga Fatema Parpia Eveline T. Konje Adolfine Hokororo Stephen E. Mshana
author_sort	Delfina R. Msanga
title	High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
title_short	High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
title_full	High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
title_fullStr	High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
title_full_unstemmed	High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action
title_sort	high mortality among premature neonates with positive blood culture neonatal sepsis in a tertiary hospital, tanzania: a call for action
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b74a3a210a194b1a9ae254b042f54a9d
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High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action

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