Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study

Background: Triple test was a breakthrough in the initial screening of breast cancer due to its high sensitivity, but it has few limitations. To overcome those limitations, we developed a novel quadruple score which included physical examination, ultrasound, mammography, and fine-needle aspiration c...

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Autores principales:	Swagata Brahmachari, Vikram Vasuniya, Soma Mukherjee, Aditi Chaurasia
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	breast cancer fine-needle aspiration cytology mammography quadruple test score breast sonography breast lump triple test assessment Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/b74ae3822c6b41229e44268dcd52dbc3
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spelling	oai:doaj.org-article:b74ae3822c6b41229e44268dcd52dbc32021-11-19T12:15:53ZQuadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study0975-740610.4103/jpbs.jpbs_219_21https://doaj.org/article/b74ae3822c6b41229e44268dcd52dbc32021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1381;epage=1385;aulast=Brahmacharihttps://doaj.org/toc/0975-7406Background: Triple test was a breakthrough in the initial screening of breast cancer due to its high sensitivity, but it has few limitations. To overcome those limitations, we developed a novel quadruple score which included physical examination, ultrasound, mammography, and fine-needle aspiration cytology (FNAC). Aim: The aim of this study was to test the sensitivity, specificity, negative predictive value (NPV), and positive predictive value of a novel quadruple score for the initial screening of breast cancer. Methodology: This retrospective study was conducted on 320 patients having breast lump to the Breast Cancer Outpatient Department of AIIMS, Bhopal. The physical examination findings, breast sonography findings, mammography, and FNAC findings were recorded in the set pro forma, these were later analyzed, and a cumulative scoring was done categorizing patients in the benign, dubious, and malignant category according to the QTS score. These findings were then validated and compared by histopathology. Results: Statistical results show a positive covariance σ suggesting the positive relation between them; also, the correlation coefficient was 0.9996 suggesting a strong linear correlation. On comparing the accuracy of all four variables as physical examination, USG, mammography and FNAC individually and QTS, the accuracy of QTS was highest i.e 99.44%. Conclusion: QTS is accurate and reliable diagnostic approach for evaluation of breast lumps. By using the quadruple scoring system, management of palpable breast lump will become more streamlined, providing a platform for managing discordant results, which can be followed universally.Swagata BrahmachariVikram VasuniyaSoma MukherjeeAditi ChaurasiaWolters Kluwer Medknow Publicationsarticlebreast cancerfine-needle aspiration cytologymammographyquadruple test scorebreast sonographybreast lumptriple test assessmentPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1381-1385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer fine-needle aspiration cytology mammography quadruple test score breast sonography breast lump triple test assessment Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	breast cancer fine-needle aspiration cytology mammography quadruple test score breast sonography breast lump triple test assessment Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Swagata Brahmachari Vikram Vasuniya Soma Mukherjee Aditi Chaurasia Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
description	Background: Triple test was a breakthrough in the initial screening of breast cancer due to its high sensitivity, but it has few limitations. To overcome those limitations, we developed a novel quadruple score which included physical examination, ultrasound, mammography, and fine-needle aspiration cytology (FNAC). Aim: The aim of this study was to test the sensitivity, specificity, negative predictive value (NPV), and positive predictive value of a novel quadruple score for the initial screening of breast cancer. Methodology: This retrospective study was conducted on 320 patients having breast lump to the Breast Cancer Outpatient Department of AIIMS, Bhopal. The physical examination findings, breast sonography findings, mammography, and FNAC findings were recorded in the set pro forma, these were later analyzed, and a cumulative scoring was done categorizing patients in the benign, dubious, and malignant category according to the QTS score. These findings were then validated and compared by histopathology. Results: Statistical results show a positive covariance σ suggesting the positive relation between them; also, the correlation coefficient was 0.9996 suggesting a strong linear correlation. On comparing the accuracy of all four variables as physical examination, USG, mammography and FNAC individually and QTS, the accuracy of QTS was highest i.e 99.44%. Conclusion: QTS is accurate and reliable diagnostic approach for evaluation of breast lumps. By using the quadruple scoring system, management of palpable breast lump will become more streamlined, providing a platform for managing discordant results, which can be followed universally.
format	article
author	Swagata Brahmachari Vikram Vasuniya Soma Mukherjee Aditi Chaurasia
author_facet	Swagata Brahmachari Vikram Vasuniya Soma Mukherjee Aditi Chaurasia
author_sort	Swagata Brahmachari
title	Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
title_short	Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
title_full	Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
title_fullStr	Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
title_full_unstemmed	Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study
title_sort	quadruple score: a novel scoring system for diagnosing breast lump – a retrospective pilot study
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/b74ae3822c6b41229e44268dcd52dbc3
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_version_	1718420154259341312

Quadruple score: A novel scoring system for diagnosing breast lump – A retrospective pilot study

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