ASSESMENT OF IL–12 ACTIVITY IN PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME ASSOCIATED WITH SEOUL SEROTYPE
Abstract. Immunopathological mechanisms of hemorrhagic fever with renal syndrome (HFRS) are very complex and are recognized as the cause of the basic pathophysiological abnormalities in this infection. In this report the results of investigation of IL12р70 and IL12р40 levels in serum of 22 patients...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b74bce08777f4109bba8d4eea489b2d8 |
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| Sumario: | Abstract. Immunopathological mechanisms of hemorrhagic fever with renal syndrome (HFRS) are very complex and are recognized as the cause of the basic pathophysiological abnormalities in this infection. In this report the results of investigation of IL12р70 and IL12р40 levels in serum of 22 patients with HFRS of different severity in dynamics of illness have been stated. High activity of IL12р70 in the acute phase of HFRS, associated with serotype Seoul virus has been determined. Probably, the influence of the other factors of immune system along with IL12р40 promoted the development of relative failure of cellular immunity in HFRS. (Med. Immunol., 2005, vol.7, № 1, pp 89592) |
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