Iron in Cardiovascular Disease: Challenges and Potentials

Iron is essential for many biological processes. Inadequate or excess amount of body iron can result in various pathological consequences. The pathological roles of iron in cardiovascular disease (CVD) have been intensively studied for decades. Convincing data demonstrated a detrimental effect of ir...

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Autores principales:	Shizhen Li, Xiangyu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	iron cardiovascular disease iron overload ferroptosis iron chelation Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b751784a467d42288a2533a8a64e8731
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id	oai:doaj.org-article:b751784a467d42288a2533a8a64e8731
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spelling	oai:doaj.org-article:b751784a467d42288a2533a8a64e87312021-12-01T16:00:23ZIron in Cardiovascular Disease: Challenges and Potentials2297-055X10.3389/fcvm.2021.707138https://doaj.org/article/b751784a467d42288a2533a8a64e87312021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.707138/fullhttps://doaj.org/toc/2297-055XIron is essential for many biological processes. Inadequate or excess amount of body iron can result in various pathological consequences. The pathological roles of iron in cardiovascular disease (CVD) have been intensively studied for decades. Convincing data demonstrated a detrimental effect of iron deficiency in patients with heart failure and pulmonary arterial hypertension, but it remains unclear for the pathological roles of iron in other cardiovascular diseases. Meanwhile, ferroptosis is an iron-dependent cell death that is distinct from apoptosis, necroptosis, and other types of cell death. Ferroptosis has been reported in several CVDs, namely, cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy seems to be an available strategy to ameliorate iron overload-related disorders. It is still a challenge to accurately clarify the pathological roles of iron in CVD and search for effective medical intervention. In this review, we aim to summarize the pathological roles of iron in CVD, and especially highlight the potential mechanism of ferroptosis in these diseases.Shizhen LiXiangyu ZhangFrontiers Media S.A.articleironcardiovascular diseaseiron overloadferroptosisiron chelationDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron cardiovascular disease iron overload ferroptosis iron chelation Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	iron cardiovascular disease iron overload ferroptosis iron chelation Diseases of the circulatory (Cardiovascular) system RC666-701 Shizhen Li Xiangyu Zhang Iron in Cardiovascular Disease: Challenges and Potentials
description	Iron is essential for many biological processes. Inadequate or excess amount of body iron can result in various pathological consequences. The pathological roles of iron in cardiovascular disease (CVD) have been intensively studied for decades. Convincing data demonstrated a detrimental effect of iron deficiency in patients with heart failure and pulmonary arterial hypertension, but it remains unclear for the pathological roles of iron in other cardiovascular diseases. Meanwhile, ferroptosis is an iron-dependent cell death that is distinct from apoptosis, necroptosis, and other types of cell death. Ferroptosis has been reported in several CVDs, namely, cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy seems to be an available strategy to ameliorate iron overload-related disorders. It is still a challenge to accurately clarify the pathological roles of iron in CVD and search for effective medical intervention. In this review, we aim to summarize the pathological roles of iron in CVD, and especially highlight the potential mechanism of ferroptosis in these diseases.
format	article
author	Shizhen Li Xiangyu Zhang
author_facet	Shizhen Li Xiangyu Zhang
author_sort	Shizhen Li
title	Iron in Cardiovascular Disease: Challenges and Potentials
title_short	Iron in Cardiovascular Disease: Challenges and Potentials
title_full	Iron in Cardiovascular Disease: Challenges and Potentials
title_fullStr	Iron in Cardiovascular Disease: Challenges and Potentials
title_full_unstemmed	Iron in Cardiovascular Disease: Challenges and Potentials
title_sort	iron in cardiovascular disease: challenges and potentials
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b751784a467d42288a2533a8a64e8731
work_keys_str_mv	AT shizhenli ironincardiovasculardiseasechallengesandpotentials AT xiangyuzhang ironincardiovasculardiseasechallengesandpotentials
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Iron in Cardiovascular Disease: Challenges and Potentials

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