INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION

Objective: Drug-drug interactions are an important cause of adverse drug events. The preventable or manageable nature of drug-drug interactions puts them at the center of interventions. Since hematopoietic stem cell transplantation is a challenging and multi-drug process, drug-drug interactions are...

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Autores principales:	Ayse Gunay, Eren Demirpolat, Ali Unal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/b7547484911c423580298d661bf6e336
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spelling	oai:doaj.org-article:b7547484911c423580298d661bf6e3362021-11-10T04:37:13ZINVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION2531-137910.1016/j.htct.2021.10.1053https://doaj.org/article/b7547484911c423580298d661bf6e3362021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921012001https://doaj.org/toc/2531-1379Objective: Drug-drug interactions are an important cause of adverse drug events. The preventable or manageable nature of drug-drug interactions puts them at the center of interventions. Since hematopoietic stem cell transplantation is a challenging and multi-drug process, drug-drug interactions are frequently encountered. Methodology: In our study, the drugs used by a total of 100 patients with 50 autologous and 50 allogeneic bone marrow transplants for 10 days before transplantation, on the day of transplantation and for 10 days after transplantation were examined retrospectively in terms of interaction. Two paid softwares and two free softwares were used to examine interactions. The obtained data were analyzed with Microsoft Excel program. Results: A total of 3805 interactions were observed in the 21-day period in 50 patients who underwent allogeneic stem cell transplantation, and these interactions occurred with the repetition of 1017 interactions in different patients. For the same period in 50 autologous stem cell transplant patients, 2906 interactions were detected, and this number occurred with 725 different interactions seen in different patients. It has been understood that anti-infectives cause serious interaction load. Conclusion: Hematopoietic stem cell transplantation is a period in which prophylactic or anti-infective treatment for the detected microorganism is applied intensively. Interactions of anti-infectives with each other and with other drugs in the treatment regimen are frequently encountered during the transport process. Interactions should be identified and their clinical significance should be demonstrated. It should be handled with the partnership of physician-clinical pharmacist.Ayse GunayEren DemirpolatAli UnalElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S48-S49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Ayse Gunay Eren Demirpolat Ali Unal INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
description	Objective: Drug-drug interactions are an important cause of adverse drug events. The preventable or manageable nature of drug-drug interactions puts them at the center of interventions. Since hematopoietic stem cell transplantation is a challenging and multi-drug process, drug-drug interactions are frequently encountered. Methodology: In our study, the drugs used by a total of 100 patients with 50 autologous and 50 allogeneic bone marrow transplants for 10 days before transplantation, on the day of transplantation and for 10 days after transplantation were examined retrospectively in terms of interaction. Two paid softwares and two free softwares were used to examine interactions. The obtained data were analyzed with Microsoft Excel program. Results: A total of 3805 interactions were observed in the 21-day period in 50 patients who underwent allogeneic stem cell transplantation, and these interactions occurred with the repetition of 1017 interactions in different patients. For the same period in 50 autologous stem cell transplant patients, 2906 interactions were detected, and this number occurred with 725 different interactions seen in different patients. It has been understood that anti-infectives cause serious interaction load. Conclusion: Hematopoietic stem cell transplantation is a period in which prophylactic or anti-infective treatment for the detected microorganism is applied intensively. Interactions of anti-infectives with each other and with other drugs in the treatment regimen are frequently encountered during the transport process. Interactions should be identified and their clinical significance should be demonstrated. It should be handled with the partnership of physician-clinical pharmacist.
format	article
author	Ayse Gunay Eren Demirpolat Ali Unal
author_facet	Ayse Gunay Eren Demirpolat Ali Unal
author_sort	Ayse Gunay
title	INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_short	INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full	INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_fullStr	INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full_unstemmed	INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_sort	investigation of drug-drug interactions involving anti-infective drugs in patients underwent hematopoietic stem cell transplantation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b7547484911c423580298d661bf6e336
work_keys_str_mv	AT aysegunay investigationofdrugdruginteractionsinvolvingantiinfectivedrugsinpatientsunderwenthematopoieticstemcelltransplantation AT erendemirpolat investigationofdrugdruginteractionsinvolvingantiinfectivedrugsinpatientsunderwenthematopoieticstemcelltransplantation AT aliunal investigationofdrugdruginteractionsinvolvingantiinfectivedrugsinpatientsunderwenthematopoieticstemcelltransplantation
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INVESTIGATION OF DRUG-DRUG INTERACTIONS INVOLVING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT HEMATOPOIETIC STEM CELL TRANSPLANTATION

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