Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis

It is possible to call single-nucleotide variant (SNV) in cell-free DNA (cfDNA), but the accuracy of detection is often affected by low tumour cfDNA content. Here, the authors develop a method, cfSNV, and show that it can be used even for medium-coverage whole exome sequencing of cfDNA.

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Autores principales:	Shuo Li, Zorawar S. Noor, Weihua Zeng, Mary L. Stackpole, Xiaohui Ni, Yonggang Zhou, Zuyang Yuan, Wing Hung Wong, Vatche G. Agopian, Steven M. Dubinett, Frank Alber, Wenyuan Li, Edward B. Garon, Xianghong Jasmine Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b75641b56a1844ef8994d8abd02e0b66
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spelling	oai:doaj.org-article:b75641b56a1844ef8994d8abd02e0b662021-12-02T15:23:10ZSensitive detection of tumor mutations from blood and its application to immunotherapy prognosis10.1038/s41467-021-24457-22041-1723https://doaj.org/article/b75641b56a1844ef8994d8abd02e0b662021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24457-2https://doaj.org/toc/2041-1723It is possible to call single-nucleotide variant (SNV) in cell-free DNA (cfDNA), but the accuracy of detection is often affected by low tumour cfDNA content. Here, the authors develop a method, cfSNV, and show that it can be used even for medium-coverage whole exome sequencing of cfDNA.Shuo LiZorawar S. NoorWeihua ZengMary L. StackpoleXiaohui NiYonggang ZhouZuyang YuanWing Hung WongVatche G. AgopianSteven M. DubinettFrank AlberWenyuan LiEdward B. GaronXianghong Jasmine ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuo Li Zorawar S. Noor Weihua Zeng Mary L. Stackpole Xiaohui Ni Yonggang Zhou Zuyang Yuan Wing Hung Wong Vatche G. Agopian Steven M. Dubinett Frank Alber Wenyuan Li Edward B. Garon Xianghong Jasmine Zhou Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
description	It is possible to call single-nucleotide variant (SNV) in cell-free DNA (cfDNA), but the accuracy of detection is often affected by low tumour cfDNA content. Here, the authors develop a method, cfSNV, and show that it can be used even for medium-coverage whole exome sequencing of cfDNA.
format	article
author	Shuo Li Zorawar S. Noor Weihua Zeng Mary L. Stackpole Xiaohui Ni Yonggang Zhou Zuyang Yuan Wing Hung Wong Vatche G. Agopian Steven M. Dubinett Frank Alber Wenyuan Li Edward B. Garon Xianghong Jasmine Zhou
author_facet	Shuo Li Zorawar S. Noor Weihua Zeng Mary L. Stackpole Xiaohui Ni Yonggang Zhou Zuyang Yuan Wing Hung Wong Vatche G. Agopian Steven M. Dubinett Frank Alber Wenyuan Li Edward B. Garon Xianghong Jasmine Zhou
author_sort	Shuo Li
title	Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
title_short	Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
title_full	Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
title_fullStr	Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
title_full_unstemmed	Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
title_sort	sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b75641b56a1844ef8994d8abd02e0b66
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Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis

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