MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.

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Bibliographic Details
Main Authors: Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng, Ziad Mallat
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763
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Summary:Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.

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