MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.

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Autores principales:	Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng, Ziad Mallat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763
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spelling	oai:doaj.org-article:b75b1e786f494ff79643fc1b0ffb57632021-12-02T17:06:13ZMARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism10.1038/ncomms159862041-1723https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb57632017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15986https://doaj.org/toc/2041-1723Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.Xuan LiSarah ThomeXiaodan MaMamta Amrute-NayakAlison FiniganLauren KittLeanne MastersJohn R. JamesYuguang ShiGuoyu MengZiad MallatNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuan Li Sarah Thome Xiaodan Ma Mamta Amrute-Nayak Alison Finigan Lauren Kitt Leanne Masters John R. James Yuguang Shi Guoyu Meng Ziad Mallat MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
description	Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.
format	article
author	Xuan Li Sarah Thome Xiaodan Ma Mamta Amrute-Nayak Alison Finigan Lauren Kitt Leanne Masters John R. James Yuguang Shi Guoyu Meng Ziad Mallat
author_facet	Xuan Li Sarah Thome Xiaodan Ma Mamta Amrute-Nayak Alison Finigan Lauren Kitt Leanne Masters John R. James Yuguang Shi Guoyu Meng Ziad Mallat
author_sort	Xuan Li
title	MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
title_short	MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
title_full	MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
title_fullStr	MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
title_full_unstemmed	MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
title_sort	mark4 regulates nlrp3 positioning and inflammasome activation through a microtubule-dependent mechanism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763
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MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

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