MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.

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Detalles Bibliográficos
Autores principales: Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng, Ziad Mallat
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763
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