MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|