Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease

Niloufar Shashaani,1 Reza Shiari,2 Abdullah Karimi,3 Shima Salehi,4 Roxana Ghanaei,3 Mehrnoush Hassas Yeganeh,2 Sara Shiari,1 Khosro Rahmani,2 Vadood Javadi Parvaneh2 1Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Pediatric Rheumatology, Mofid Chil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shashaani N, Shiari R, Karimi A, Salehi S, Ghanaei R, Hassas Yeganeh M, Shiari S, Rahmani K, Javadi Parvaneh V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	kawasaki disease coronary artery aneurysm ivig-resistant kobayashi sano egami Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/b75cec9ea320435a9c10d5699e9948d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b75cec9ea320435a9c10d5699e9948d0
record_format	dspace
spelling	oai:doaj.org-article:b75cec9ea320435a9c10d5699e9948d02021-12-02T10:52:47ZDetermination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease1179-156Xhttps://doaj.org/article/b75cec9ea320435a9c10d5699e9948d02020-08-01T00:00:00Zhttps://www.dovepress.com/determination-of-the-relationship-between-kobayashi-sano-and-egami-cri-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XNiloufar Shashaani,1 Reza Shiari,2 Abdullah Karimi,3 Shima Salehi,4 Roxana Ghanaei,3 Mehrnoush Hassas Yeganeh,2 Sara Shiari,1 Khosro Rahmani,2 Vadood Javadi Parvaneh2 1Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Pediatric Rheumatology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Department of Infectious Diseases, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, IranCorrespondence: Reza Shiari Tel +98-21-22227033Email shiareza@yahoo.comIntroduction: Kawasaki disease (KD) is a systemic vasculitis that occurs mostly in children under five years old. Kawasaki affects the middle-size arteries, especially the coronary arteries. Therefore, without adequate treatment, it may cause coronary artery aneurysm in 25% of patients. The purpose of this study was to investigate the relationship between Kobayashi, Sano, and Egami criterions with coronary artery aneurysm in KD patients during the last ten years and to identify risk factors in patients with intravenous immunoglobulin (IVIG)-resistant and coronary artery aneurysms.Methodology: Medical records of 363 Kawasaki patients referred during 2008– 2017 were reviewed. Patients’ demographic data and Kobayashi, Sano, and Egami scores of each patient were calculated. Based on echocardiographic findings, cases of coronary artery aneurysm were determined. Sensitivity, specificity, positive and negative predictive value, and the accuracy of each criterion were determined to predicting IVIG resistance and detect coronary artery aneurysm.Results: There was a slight relationship between IVIG-resistance in Kawasaki children and its prediction based on the Kobayashi risk score, but no relationship was found between the Egami and Sano criteria. Sixty-three patients (17.4%) had coronary artery lesions (CALs) on time of diagnosis. There were no statistically significant differences between gender and mean age of children with and without CALs. Also, there was no significant relationship between coronary artery aneurysm in Kawasaki children and its prediction based on the above three risk factors. The area under the ROC-curve of all three risk measures of Kobayashi, Egami, and Sano indicated that all three criteria were not useful in predicting CALs.Conclusion: Despite the low accuracy of the three above criteria to predictive of patients with IVIG resistance, it seems that the variables of age, duration of fever, and C-reactive protein (CRP) are more useful than other variables and may be utilized to evaluate patients by establishing a more appropriate cut-off point.Keywords: Kawasaki disease, coronary artery aneurysm, IVIG-resistant, Kobayashi, Sano, EgamiShashaani NShiari RKarimi ASalehi SGhanaei RHassas Yeganeh MShiari SRahmani KJavadi Parvaneh VDove Medical Pressarticlekawasaki diseasecoronary artery aneurysmivig-resistantkobayashisanoegamiDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 187-192 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	kawasaki disease coronary artery aneurysm ivig-resistant kobayashi sano egami Diseases of the musculoskeletal system RC925-935
spellingShingle	kawasaki disease coronary artery aneurysm ivig-resistant kobayashi sano egami Diseases of the musculoskeletal system RC925-935 Shashaani N Shiari R Karimi A Salehi S Ghanaei R Hassas Yeganeh M Shiari S Rahmani K Javadi Parvaneh V Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
description	Niloufar Shashaani,1 Reza Shiari,2 Abdullah Karimi,3 Shima Salehi,4 Roxana Ghanaei,3 Mehrnoush Hassas Yeganeh,2 Sara Shiari,1 Khosro Rahmani,2 Vadood Javadi Parvaneh2 1Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Pediatric Rheumatology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Department of Infectious Diseases, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, IranCorrespondence: Reza Shiari Tel +98-21-22227033Email shiareza@yahoo.comIntroduction: Kawasaki disease (KD) is a systemic vasculitis that occurs mostly in children under five years old. Kawasaki affects the middle-size arteries, especially the coronary arteries. Therefore, without adequate treatment, it may cause coronary artery aneurysm in 25% of patients. The purpose of this study was to investigate the relationship between Kobayashi, Sano, and Egami criterions with coronary artery aneurysm in KD patients during the last ten years and to identify risk factors in patients with intravenous immunoglobulin (IVIG)-resistant and coronary artery aneurysms.Methodology: Medical records of 363 Kawasaki patients referred during 2008– 2017 were reviewed. Patients’ demographic data and Kobayashi, Sano, and Egami scores of each patient were calculated. Based on echocardiographic findings, cases of coronary artery aneurysm were determined. Sensitivity, specificity, positive and negative predictive value, and the accuracy of each criterion were determined to predicting IVIG resistance and detect coronary artery aneurysm.Results: There was a slight relationship between IVIG-resistance in Kawasaki children and its prediction based on the Kobayashi risk score, but no relationship was found between the Egami and Sano criteria. Sixty-three patients (17.4%) had coronary artery lesions (CALs) on time of diagnosis. There were no statistically significant differences between gender and mean age of children with and without CALs. Also, there was no significant relationship between coronary artery aneurysm in Kawasaki children and its prediction based on the above three risk factors. The area under the ROC-curve of all three risk measures of Kobayashi, Egami, and Sano indicated that all three criteria were not useful in predicting CALs.Conclusion: Despite the low accuracy of the three above criteria to predictive of patients with IVIG resistance, it seems that the variables of age, duration of fever, and C-reactive protein (CRP) are more useful than other variables and may be utilized to evaluate patients by establishing a more appropriate cut-off point.Keywords: Kawasaki disease, coronary artery aneurysm, IVIG-resistant, Kobayashi, Sano, Egami
format	article
author	Shashaani N Shiari R Karimi A Salehi S Ghanaei R Hassas Yeganeh M Shiari S Rahmani K Javadi Parvaneh V
author_facet	Shashaani N Shiari R Karimi A Salehi S Ghanaei R Hassas Yeganeh M Shiari S Rahmani K Javadi Parvaneh V
author_sort	Shashaani N
title	Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
title_short	Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
title_full	Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
title_fullStr	Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
title_full_unstemmed	Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease
title_sort	determination of the relationship between kobayashi, sano, and egami criteria and prevalence of intravenous immunoglobulin resistance and coronary artery aneurysm in iranian children with kawasaki disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b75cec9ea320435a9c10d5699e9948d0
work_keys_str_mv	AT shashaanin determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT shiarir determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT karimia determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT salehis determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT ghanaeir determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT hassasyeganehm determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT shiaris determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT rahmanik determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease AT javadiparvanehv determinationoftherelationshipbetweenkobayashisanoandegamicriteriaandprevalenceofintravenousimmunoglobulinresistanceandcoronaryarteryaneurysminiranianchildrenwithkawasakidisease
_version_	1718396552560508928

Determination of the Relationship Between Kobayashi, Sano, and Egami Criteria and Prevalence of Intravenous Immunoglobulin Resistance and Coronary Artery Aneurysm in Iranian Children with Kawasaki Disease

Ejemplares similares