Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8

Abstract It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver tr...

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Autores principales:	Chuanhui Peng, Wendi Hu, Xiaoyu Weng, Rongliang Tong, Shaobing Cheng, Chaofeng Ding, Heng Xiao, Zhen Lv, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b75ea3b7c3f744488afa098af36caa35
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spelling	oai:doaj.org-article:b75ea3b7c3f744488afa098af36caa352021-12-02T11:50:56ZOver Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL810.1038/s41598-017-04045-52045-2322https://doaj.org/article/b75ea3b7c3f744488afa098af36caa352017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04045-5https://doaj.org/toc/2045-2322Abstract It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver transplantation and 84 HCC patients following liver resection), and found that PANDA was down-regulated in HCC. Thereafter we explored its function in cancer biology by inversing its low expression. Surprisingly, overexpression of PANDA promoted HCC proliferation and carcinogenesis in vitro and in vivo. Mechanistically, PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence. Therefore, our research help to better understand the complex role of PANDA in HCC, and suggest more thoughtful strategies should be applied before it can be treated as a potential therapeutic target.Chuanhui PengWendi HuXiaoyu WengRongliang TongShaobing ChengChaofeng DingHeng XiaoZhen LvHaiyang XieLin ZhouJian WuShusen ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chuanhui Peng Wendi Hu Xiaoyu Weng Rongliang Tong Shaobing Cheng Chaofeng Ding Heng Xiao Zhen Lv Haiyang Xie Lin Zhou Jian Wu Shusen Zheng Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
description	Abstract It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver transplantation and 84 HCC patients following liver resection), and found that PANDA was down-regulated in HCC. Thereafter we explored its function in cancer biology by inversing its low expression. Surprisingly, overexpression of PANDA promoted HCC proliferation and carcinogenesis in vitro and in vivo. Mechanistically, PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence. Therefore, our research help to better understand the complex role of PANDA in HCC, and suggest more thoughtful strategies should be applied before it can be treated as a potential therapeutic target.
format	article
author	Chuanhui Peng Wendi Hu Xiaoyu Weng Rongliang Tong Shaobing Cheng Chaofeng Ding Heng Xiao Zhen Lv Haiyang Xie Lin Zhou Jian Wu Shusen Zheng
author_facet	Chuanhui Peng Wendi Hu Xiaoyu Weng Rongliang Tong Shaobing Cheng Chaofeng Ding Heng Xiao Zhen Lv Haiyang Xie Lin Zhou Jian Wu Shusen Zheng
author_sort	Chuanhui Peng
title	Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
title_short	Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
title_full	Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
title_fullStr	Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
title_full_unstemmed	Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
title_sort	over expression of long non-coding rna panda promotes hepatocellular carcinoma by inhibiting senescence associated inflammatory factor il8
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b75ea3b7c3f744488afa098af36caa35
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Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8

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