Ultrasound-assisted preparation of calcium malate and its absorption.

In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-li...

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Autores principales:	Wuren Ma, Yizhou Lv, Xuan Cao, Mengzhi Wang, Yunpeng Fan, Yuanyuan Shan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b760799f10684c0bae30850764a0f026
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spelling	oai:doaj.org-article:b760799f10684c0bae30850764a0f0262021-12-02T20:09:10ZUltrasound-assisted preparation of calcium malate and its absorption.1932-620310.1371/journal.pone.0254583https://doaj.org/article/b760799f10684c0bae30850764a0f0262021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254583https://doaj.org/toc/1932-6203In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material.Wuren MaYizhou LvXuan CaoMengzhi WangYunpeng FanYuanyuan ShanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254583 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wuren Ma Yizhou Lv Xuan Cao Mengzhi Wang Yunpeng Fan Yuanyuan Shan Ultrasound-assisted preparation of calcium malate and its absorption.
description	In this experiment, response surface methodology was used to study the preparation of malic acid calcium salt from bovine bones assisted by ultrasonication. The results showed that the optimum conditions for ultrasound-assisted preparation of calcium malate from bovine bone were as follows: solid-liquid ratio 1:15, solid-acid ratio 1:1.5, ultrasonic power 200 W, ultrasonic temperature 35°C, and ultrasonication time 17 min. The efficiency of calcium recovery was 66.16%, and the purity was 92.54%. After three ultrasonic treatments of 17 min each, the calcium malate conversion rate of bovine bone reached 95.73%. Animal experiments showed that feeding bovine bone-derived calcium malate significantly increased alkaline phosphatase (ALP) activity and bone calcium content, reduced tartrate-resistant acid phosphatase (TRAP) activity, and maintained the balance of serum calcium and phosphorus. These results indicated that the ultrasonic method effectively ionized calcium in bovine bone, which provides a reference point for the industrial production of calcium products with bovine bone as the raw material.
format	article
author	Wuren Ma Yizhou Lv Xuan Cao Mengzhi Wang Yunpeng Fan Yuanyuan Shan
author_facet	Wuren Ma Yizhou Lv Xuan Cao Mengzhi Wang Yunpeng Fan Yuanyuan Shan
author_sort	Wuren Ma
title	Ultrasound-assisted preparation of calcium malate and its absorption.
title_short	Ultrasound-assisted preparation of calcium malate and its absorption.
title_full	Ultrasound-assisted preparation of calcium malate and its absorption.
title_fullStr	Ultrasound-assisted preparation of calcium malate and its absorption.
title_full_unstemmed	Ultrasound-assisted preparation of calcium malate and its absorption.
title_sort	ultrasound-assisted preparation of calcium malate and its absorption.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b760799f10684c0bae30850764a0f026
work_keys_str_mv	AT wurenma ultrasoundassistedpreparationofcalciummalateanditsabsorption AT yizhoulv ultrasoundassistedpreparationofcalciummalateanditsabsorption AT xuancao ultrasoundassistedpreparationofcalciummalateanditsabsorption AT mengzhiwang ultrasoundassistedpreparationofcalciummalateanditsabsorption AT yunpengfan ultrasoundassistedpreparationofcalciummalateanditsabsorption AT yuanyuanshan ultrasoundassistedpreparationofcalciummalateanditsabsorption
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Ultrasound-assisted preparation of calcium malate and its absorption.

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