Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma

Abstract This study was designed to explore the relationship between epidermal growth factor receptor (EGFR) CA repeats polymorphism and protein expression in oral cavity squamous cell carcinoma (OSCC). A total of 194 OSCCs were examined for EGFR protein overexpression, gene copy number and the leng...

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Autores principales:	Shiang-Fu Huang, Huei-Tzu Chien, Wen-Yu Chuang, Chih-Hsiung Lai, Sou-De Cheng, Chun-Ta Liao, Hung-Ming Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b760cba4ad5c42d0a1f836131337a9ec
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spelling	oai:doaj.org-article:b760cba4ad5c42d0a1f836131337a9ec2021-12-02T11:53:03ZEpidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma10.1038/s41598-017-04954-52045-2322https://doaj.org/article/b760cba4ad5c42d0a1f836131337a9ec2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04954-5https://doaj.org/toc/2045-2322Abstract This study was designed to explore the relationship between epidermal growth factor receptor (EGFR) CA repeats polymorphism and protein expression in oral cavity squamous cell carcinoma (OSCC). A total of 194 OSCCs were examined for EGFR protein overexpression, gene copy number and the length of their CA repeats. The length of the EGFR CA repeats was found not to be associated with EGFR gene copy number or with protein overexpression. To exclude the effect of EGFR gene copy number on protein overexpression, only those OSCC tumors with disomy of the EGFR gene were included in further analysis. In this subgroup, EGFR protein overexpression was significantly associated with poor differentiation of the tumor cells and lymph node metastasis, especially extra-capsular spread. However, EGFR CA repeats were not related to any clinicopathological factor. Interestingly, patients genetically found to have the EGFR CA repeats SS genotype and having tumors with EGFR protein overexpression were found to have a worst prognosis in terms of disease-free survival (DFS) (HR = 2.68; 95% CI, 1.03–6.98) after multivariate adjustment. The present study demonstrates that concurrent overexpression of EGFR protein in the presence genetically of the SS form CA repeats acts as a predictor for poor DFS.Shiang-Fu HuangHuei-Tzu ChienWen-Yu ChuangChih-Hsiung LaiSou-De ChengChun-Ta LiaoHung-Ming WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiang-Fu Huang Huei-Tzu Chien Wen-Yu Chuang Chih-Hsiung Lai Sou-De Cheng Chun-Ta Liao Hung-Ming Wang Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
description	Abstract This study was designed to explore the relationship between epidermal growth factor receptor (EGFR) CA repeats polymorphism and protein expression in oral cavity squamous cell carcinoma (OSCC). A total of 194 OSCCs were examined for EGFR protein overexpression, gene copy number and the length of their CA repeats. The length of the EGFR CA repeats was found not to be associated with EGFR gene copy number or with protein overexpression. To exclude the effect of EGFR gene copy number on protein overexpression, only those OSCC tumors with disomy of the EGFR gene were included in further analysis. In this subgroup, EGFR protein overexpression was significantly associated with poor differentiation of the tumor cells and lymph node metastasis, especially extra-capsular spread. However, EGFR CA repeats were not related to any clinicopathological factor. Interestingly, patients genetically found to have the EGFR CA repeats SS genotype and having tumors with EGFR protein overexpression were found to have a worst prognosis in terms of disease-free survival (DFS) (HR = 2.68; 95% CI, 1.03–6.98) after multivariate adjustment. The present study demonstrates that concurrent overexpression of EGFR protein in the presence genetically of the SS form CA repeats acts as a predictor for poor DFS.
format	article
author	Shiang-Fu Huang Huei-Tzu Chien Wen-Yu Chuang Chih-Hsiung Lai Sou-De Cheng Chun-Ta Liao Hung-Ming Wang
author_facet	Shiang-Fu Huang Huei-Tzu Chien Wen-Yu Chuang Chih-Hsiung Lai Sou-De Cheng Chun-Ta Liao Hung-Ming Wang
author_sort	Shiang-Fu Huang
title	Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
title_short	Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
title_full	Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
title_fullStr	Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
title_full_unstemmed	Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma
title_sort	epidermal growth factor receptor intron-1 ca repeat polymorphism on protein expression and clinical outcome in taiwanese oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b760cba4ad5c42d0a1f836131337a9ec
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Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma

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