Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study

Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study

Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for therapy resistance and tumor spreading in the brain, reportedly upregulate aldehyde dehydrogenase isoform-1A3 (ALDH1A3) which can be inhibited by disulfiram (DSF), an FDA-approved drug formerly presc...

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Bibliographic Details
Main Authors: Lisa Zirjacks, Nicolai Stransky, Lukas Klumpp, Lukas Prause, Franziska Eckert, Daniel Zips, Sabine Schleicher, Rupert Handgretinger, Stephan M. Huber, Katrin Ganser
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
brain tumor
primary spheroid culture
tumor-initiating cells
propidium iodide
Nicoletti staining
survival fraction
Microbiology
QR1-502
Online Access:https://doaj.org/article/b762c8c38f64496dbf25ca231191fa66
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https://doaj.org/article/b762c8c38f64496dbf25ca231191fa66

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