Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

P Daisy, K SaipriyaPostgraduate and Research Department of Biotechnology and Bioinformatics, Holy Cross College, Teppakulam, Trichy, Tamil Nadu, IndiaAbstract: Cassia fistula stem bark was used for the preparation of aqueous extract and synthesis of gold nanoparticles to evaluate the hypoglycemic ef...

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Autores principales:	Saipriya K, Daisy P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b762d3b1a6d3480d92e5f641779bbe63
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spelling	oai:doaj.org-article:b762d3b1a6d3480d92e5f641779bbe632021-12-02T02:28:09ZBiochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus1176-91141178-2013https://doaj.org/article/b762d3b1a6d3480d92e5f641779bbe632012-03-01T00:00:00Zhttp://www.dovepress.com/biochemical-analysis-of-cassia-fistula-aqueous-extract-and-phytochemic-a9430https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013P Daisy, K SaipriyaPostgraduate and Research Department of Biotechnology and Bioinformatics, Holy Cross College, Teppakulam, Trichy, Tamil Nadu, IndiaAbstract: Cassia fistula stem bark was used for the preparation of aqueous extract and synthesis of gold nanoparticles to evaluate the hypoglycemic effects of the plant. The synthesized gold nanoparticles were characterized by ultraviolet-visible spectroscopy for their absorbance pattern, Fourier transform infrared spectroscopy to identify possible functional groups, and scanning electron microscopy to determine the size of the nanoparticles. The present investigation reports the efficacy of the gold nanoparticles as promising in the treatment of hyperglycemia. Body weight, serum glucose concentrations, liver function tests, kidney function tests, and lipid profile were analyzed. A significantly larger decrease in serum biochemistry parameters and an increase in body weight, total protein levels, and high-density lipoprotein were observed in rats with streptozotocin-induced diabetes treated with gold nanoparticles than in the ones treated with the aqueous extract. The results of this study confirm that C. fistula gold nanoparticles have promising antidiabetic properties.Keywords: diabetes mellitus, Cassia fistula, aqueous, gold nanoparticles, biochemical analysisSaipriya KDaisy PDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1189-1202 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Saipriya K Daisy P Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
description	P Daisy, K SaipriyaPostgraduate and Research Department of Biotechnology and Bioinformatics, Holy Cross College, Teppakulam, Trichy, Tamil Nadu, IndiaAbstract: Cassia fistula stem bark was used for the preparation of aqueous extract and synthesis of gold nanoparticles to evaluate the hypoglycemic effects of the plant. The synthesized gold nanoparticles were characterized by ultraviolet-visible spectroscopy for their absorbance pattern, Fourier transform infrared spectroscopy to identify possible functional groups, and scanning electron microscopy to determine the size of the nanoparticles. The present investigation reports the efficacy of the gold nanoparticles as promising in the treatment of hyperglycemia. Body weight, serum glucose concentrations, liver function tests, kidney function tests, and lipid profile were analyzed. A significantly larger decrease in serum biochemistry parameters and an increase in body weight, total protein levels, and high-density lipoprotein were observed in rats with streptozotocin-induced diabetes treated with gold nanoparticles than in the ones treated with the aqueous extract. The results of this study confirm that C. fistula gold nanoparticles have promising antidiabetic properties.Keywords: diabetes mellitus, Cassia fistula, aqueous, gold nanoparticles, biochemical analysis
format	article
author	Saipriya K Daisy P
author_facet	Saipriya K Daisy P
author_sort	Saipriya K
title	Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
title_short	Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
title_full	Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
title_fullStr	Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
title_full_unstemmed	Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
title_sort	biochemical analysis of cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/b762d3b1a6d3480d92e5f641779bbe63
work_keys_str_mv	AT saipriyak biochemicalanalysisofcassiafistulaaqueousextractandphytochemicallysynthesizedgoldnanoparticlesashypoglycemictreatmentfordiabetesmellitus AT daisyp biochemicalanalysisofcassiafistulaaqueousextractandphytochemicallysynthesizedgoldnanoparticlesashypoglycemictreatmentfordiabetesmellitus
_version_	1718402491232550912

Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus

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