Flavonoids as Inhibitors of Bacterial Efflux Pumps

Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances. Hence, in a number of studies during the last fe...

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Autores principales:	Martin Waditzer, Franz Bucar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavonoids efflux pumps bacterial membrane antibiotics transport proteins Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/b768eac1015f4a95abc9c6bdfd7c6eef
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spelling	oai:doaj.org-article:b768eac1015f4a95abc9c6bdfd7c6eef2021-11-25T18:28:15ZFlavonoids as Inhibitors of Bacterial Efflux Pumps10.3390/molecules262269041420-3049https://doaj.org/article/b768eac1015f4a95abc9c6bdfd7c6eef2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6904https://doaj.org/toc/1420-3049Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances. Hence, in a number of studies during the last few years, different classes of plant secondary metabolites as resistance-modifying agents have been carried out. In this review, we present the role of flavonoids as inhibitors of bacterial efflux pumps. Active compounds could be identified in the subclasses of chalcones, flavan-3-ols, flavanones, flavones, flavonols, flavonolignans and isoflavones; by far the majority of compounds were aglycones, although some glycosides like kaempferol glycosides with p-coumaroyl acylation showed remarkable results. <i>Staphylococcus aureus</i> NorA pump was the focus of many studies, followed by mycobacteria, whereas Gram-negative bacteria are still under-investigated.Martin WaditzerFranz BucarMDPI AGarticleflavonoidsefflux pumpsbacterial membraneantibioticstransport proteinsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6904, p 6904 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids efflux pumps bacterial membrane antibiotics transport proteins Organic chemistry QD241-441
spellingShingle	flavonoids efflux pumps bacterial membrane antibiotics transport proteins Organic chemistry QD241-441 Martin Waditzer Franz Bucar Flavonoids as Inhibitors of Bacterial Efflux Pumps
description	Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances. Hence, in a number of studies during the last few years, different classes of plant secondary metabolites as resistance-modifying agents have been carried out. In this review, we present the role of flavonoids as inhibitors of bacterial efflux pumps. Active compounds could be identified in the subclasses of chalcones, flavan-3-ols, flavanones, flavones, flavonols, flavonolignans and isoflavones; by far the majority of compounds were aglycones, although some glycosides like kaempferol glycosides with p-coumaroyl acylation showed remarkable results. <i>Staphylococcus aureus</i> NorA pump was the focus of many studies, followed by mycobacteria, whereas Gram-negative bacteria are still under-investigated.
format	article
author	Martin Waditzer Franz Bucar
author_facet	Martin Waditzer Franz Bucar
author_sort	Martin Waditzer
title	Flavonoids as Inhibitors of Bacterial Efflux Pumps
title_short	Flavonoids as Inhibitors of Bacterial Efflux Pumps
title_full	Flavonoids as Inhibitors of Bacterial Efflux Pumps
title_fullStr	Flavonoids as Inhibitors of Bacterial Efflux Pumps
title_full_unstemmed	Flavonoids as Inhibitors of Bacterial Efflux Pumps
title_sort	flavonoids as inhibitors of bacterial efflux pumps
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b768eac1015f4a95abc9c6bdfd7c6eef
work_keys_str_mv	AT martinwaditzer flavonoidsasinhibitorsofbacterialeffluxpumps AT franzbucar flavonoidsasinhibitorsofbacterialeffluxpumps
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Flavonoids as Inhibitors of Bacterial Efflux Pumps

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