Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review

Injudicious use of antibiotics has been the main driver of severe bacterial non-susceptibility to commonly available antibiotics (known as drug resistance or antimicrobial resistance), a global threat to human health and healthcare. There is an increase in the incidence and levels of resistance to a...

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Autores principales:	Kawaljeet Kaur, Sagar Reddy, Pramod Barathe, Varsha Shriram, Uttpal Anand, Jarosław Proćków, Vinay Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	antibiotics multidrug resistance nanoparticles drug efflux pumps ROS antimicrobial resistance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b76b962ca1a14e13920ced1595c69d6a
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id	oai:doaj.org-article:b76b962ca1a14e13920ced1595c69d6a
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spelling	oai:doaj.org-article:b76b962ca1a14e13920ced1595c69d6a2021-11-12T05:45:18ZCombating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review1664-302X10.3389/fmicb.2021.747019https://doaj.org/article/b76b962ca1a14e13920ced1595c69d6a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.747019/fullhttps://doaj.org/toc/1664-302XInjudicious use of antibiotics has been the main driver of severe bacterial non-susceptibility to commonly available antibiotics (known as drug resistance or antimicrobial resistance), a global threat to human health and healthcare. There is an increase in the incidence and levels of resistance to antibacterial drugs not only in nosocomial settings but also in community ones. The drying pipeline of new and effective antibiotics has further worsened the situation and is leading to a potentially “post-antibiotic era.” This requires novel and effective therapies and therapeutic agents for combating drug-resistant pathogenic microbes. Nanomaterials are emerging as potent antimicrobial agents with both bactericidal and potentiating effects reported against drug-resistant microbes. Among them, the photothermally active nanomaterials (PANs) are gaining attention for their broad-spectrum antibacterial potencies driven mainly by the photothermal effect, which is characterized by the conversion of absorbed photon energy into heat energy by the PANs. The current review capitalizes on the importance of using PANs as an effective approach for overcoming bacterial resistance to drugs. Various PANs leveraging broad-spectrum therapeutic antibacterial (both bactericidal and synergistic) potentials against drug-resistant pathogens have been discussed. The review also provides deeper mechanistic insights into the mechanisms of the action of PANs against a variety of drug-resistant pathogens with a critical evaluation of efflux pumps, cell membrane permeability, biofilm, and quorum sensing inhibition. We also discuss the use of PANs as drug carriers. This review also discusses possible cytotoxicities related to the therapeutic use of PANs and effective strategies to overcome this. Recent developments, success stories, challenges, and prospects are also presented.Kawaljeet KaurSagar ReddyPramod BaratheVarsha ShriramUttpal AnandJarosław ProćkówVinay KumarFrontiers Media S.A.articleantibioticsmultidrug resistancenanoparticlesdrug efflux pumpsROSantimicrobial resistanceMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotics multidrug resistance nanoparticles drug efflux pumps ROS antimicrobial resistance Microbiology QR1-502
spellingShingle	antibiotics multidrug resistance nanoparticles drug efflux pumps ROS antimicrobial resistance Microbiology QR1-502 Kawaljeet Kaur Sagar Reddy Pramod Barathe Varsha Shriram Uttpal Anand Jarosław Proćków Vinay Kumar Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
description	Injudicious use of antibiotics has been the main driver of severe bacterial non-susceptibility to commonly available antibiotics (known as drug resistance or antimicrobial resistance), a global threat to human health and healthcare. There is an increase in the incidence and levels of resistance to antibacterial drugs not only in nosocomial settings but also in community ones. The drying pipeline of new and effective antibiotics has further worsened the situation and is leading to a potentially “post-antibiotic era.” This requires novel and effective therapies and therapeutic agents for combating drug-resistant pathogenic microbes. Nanomaterials are emerging as potent antimicrobial agents with both bactericidal and potentiating effects reported against drug-resistant microbes. Among them, the photothermally active nanomaterials (PANs) are gaining attention for their broad-spectrum antibacterial potencies driven mainly by the photothermal effect, which is characterized by the conversion of absorbed photon energy into heat energy by the PANs. The current review capitalizes on the importance of using PANs as an effective approach for overcoming bacterial resistance to drugs. Various PANs leveraging broad-spectrum therapeutic antibacterial (both bactericidal and synergistic) potentials against drug-resistant pathogens have been discussed. The review also provides deeper mechanistic insights into the mechanisms of the action of PANs against a variety of drug-resistant pathogens with a critical evaluation of efflux pumps, cell membrane permeability, biofilm, and quorum sensing inhibition. We also discuss the use of PANs as drug carriers. This review also discusses possible cytotoxicities related to the therapeutic use of PANs and effective strategies to overcome this. Recent developments, success stories, challenges, and prospects are also presented.
format	article
author	Kawaljeet Kaur Sagar Reddy Pramod Barathe Varsha Shriram Uttpal Anand Jarosław Proćków Vinay Kumar
author_facet	Kawaljeet Kaur Sagar Reddy Pramod Barathe Varsha Shriram Uttpal Anand Jarosław Proćków Vinay Kumar
author_sort	Kawaljeet Kaur
title	Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
title_short	Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
title_full	Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
title_fullStr	Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
title_full_unstemmed	Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
title_sort	combating drug-resistant bacteria using photothermally active nanomaterials: a perspective review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b76b962ca1a14e13920ced1595c69d6a
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Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review

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