Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex

Binocular matching of orientation preference between the two eyes is a common form of binocular integration that is regarded as the basis for stereopsis. How critical period plasticity enables binocular matching under the guidance of normal visual experience has not been fully demonstrated. To inves...

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Autores principales:	Jiangping Chan, Xiangwen Hao, Qiong Liu, Jianhua Cang, Yu Gu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	critical period binocular matching E/I balance ocular dominance plasticity orientation selectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/b76ccac677594390a0df8ea44a93a677
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spelling	oai:doaj.org-article:b76ccac677594390a0df8ea44a93a6772021-12-01T09:10:35ZClosing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex1662-510210.3389/fncel.2021.749265https://doaj.org/article/b76ccac677594390a0df8ea44a93a6772021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.749265/fullhttps://doaj.org/toc/1662-5102Binocular matching of orientation preference between the two eyes is a common form of binocular integration that is regarded as the basis for stereopsis. How critical period plasticity enables binocular matching under the guidance of normal visual experience has not been fully demonstrated. To investigate how critical period closure affects the binocular matching, a critical period prolonged mouse model was constructed through the administration of bumetanide, an NKCC1 transporter antagonist. Using acute in vivo extracellular recording and molecular assay, we revealed that binocular matching was transiently disrupted due to heightened plasticity after the normal critical period, together with an increase in the density of spines and synapses, and the upregulation of GluA1 expression. Diazepam (DZ)/[(R, S)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP)] could reclose the extended critical period, and rescue the deficits in binocular matching. Furthermore, the extended critical period, alone, with normal visual experience is sufficient for the completion of binocular matching in amblyopic mice. Similarly, prolonging the critical period into adulthood by knocking out Nogo-66 receptor can prevent the normal maturation of binocular matching and depth perception. These results suggest that maintaining an optimal plasticity level during adolescence is most beneficial for the systemic maturation. Extending the critical period provides new clues for the maturation of binocular vision and may have critical implications for the treatment of amblyopia.Jiangping ChanXiangwen HaoQiong LiuQiong LiuJianhua CangJianhua CangYu GuFrontiers Media S.A.articlecritical periodbinocular matchingE/I balanceocular dominance plasticityorientation selectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	critical period binocular matching E/I balance ocular dominance plasticity orientation selectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	critical period binocular matching E/I balance ocular dominance plasticity orientation selectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jiangping Chan Xiangwen Hao Qiong Liu Qiong Liu Jianhua Cang Jianhua Cang Yu Gu Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
description	Binocular matching of orientation preference between the two eyes is a common form of binocular integration that is regarded as the basis for stereopsis. How critical period plasticity enables binocular matching under the guidance of normal visual experience has not been fully demonstrated. To investigate how critical period closure affects the binocular matching, a critical period prolonged mouse model was constructed through the administration of bumetanide, an NKCC1 transporter antagonist. Using acute in vivo extracellular recording and molecular assay, we revealed that binocular matching was transiently disrupted due to heightened plasticity after the normal critical period, together with an increase in the density of spines and synapses, and the upregulation of GluA1 expression. Diazepam (DZ)/[(R, S)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP)] could reclose the extended critical period, and rescue the deficits in binocular matching. Furthermore, the extended critical period, alone, with normal visual experience is sufficient for the completion of binocular matching in amblyopic mice. Similarly, prolonging the critical period into adulthood by knocking out Nogo-66 receptor can prevent the normal maturation of binocular matching and depth perception. These results suggest that maintaining an optimal plasticity level during adolescence is most beneficial for the systemic maturation. Extending the critical period provides new clues for the maturation of binocular vision and may have critical implications for the treatment of amblyopia.
format	article
author	Jiangping Chan Xiangwen Hao Qiong Liu Qiong Liu Jianhua Cang Jianhua Cang Yu Gu
author_facet	Jiangping Chan Xiangwen Hao Qiong Liu Qiong Liu Jianhua Cang Jianhua Cang Yu Gu
author_sort	Jiangping Chan
title	Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
title_short	Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
title_full	Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
title_fullStr	Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
title_full_unstemmed	Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex
title_sort	closing the critical period is required for the maturation of binocular integration in mouse primary visual cortex
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b76ccac677594390a0df8ea44a93a677
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Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex

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