The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repression

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Autores principales: R. C. Nayak, S. Hegde, M. J. Althoff, A. M. Wellendorf, F. Mohmoud, J. Perentesis, M. Reina-Campos, D. Reynaud, Y. Zheng, M. T. Diaz-Meco, J. Moscat, J. A. Cancelas
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b77386147192448ea2595f752699e97f
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spelling oai:doaj.org-article:b77386147192448ea2595f752699e97f2021-12-02T16:57:30ZThe signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors10.1038/s41467-018-07846-y2041-1723https://doaj.org/article/b77386147192448ea2595f752699e97f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07846-yhttps://doaj.org/toc/2041-1723The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repressionR. C. NayakS. HegdeM. J. AlthoffA. M. WellendorfF. MohmoudJ. PerentesisM. Reina-CamposD. ReynaudY. ZhengM. T. Diaz-MecoJ. MoscatJ. A. CancelasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
R. C. Nayak
S. Hegde
M. J. Althoff
A. M. Wellendorf
F. Mohmoud
J. Perentesis
M. Reina-Campos
D. Reynaud
Y. Zheng
M. T. Diaz-Meco
J. Moscat
J. A. Cancelas
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
description The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repression
format article
author R. C. Nayak
S. Hegde
M. J. Althoff
A. M. Wellendorf
F. Mohmoud
J. Perentesis
M. Reina-Campos
D. Reynaud
Y. Zheng
M. T. Diaz-Meco
J. Moscat
J. A. Cancelas
author_facet R. C. Nayak
S. Hegde
M. J. Althoff
A. M. Wellendorf
F. Mohmoud
J. Perentesis
M. Reina-Campos
D. Reynaud
Y. Zheng
M. T. Diaz-Meco
J. Moscat
J. A. Cancelas
author_sort R. C. Nayak
title The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
title_short The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
title_full The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
title_fullStr The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
title_full_unstemmed The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
title_sort signaling axis atypical protein kinase c λ/ι-satb2 mediates leukemic transformation of b-cell progenitors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/b77386147192448ea2595f752699e97f
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