Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex

In order to assess the effects of aging on the autoregulation of TAR DNA-binding protein 43 (TDP-43) and the potential effects of this on the role of TDP-43 in Amyotrophic Lateral Sclerosis (ALS), Koike et al examined post-mortem motor cortex tissue from ALS patients. They found that DNA demethylati...

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Autores principales:	Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, Akiyoshi Kakita, Osamu Onodera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b775225155e84a5488bf618023fb3c56
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spelling	oai:doaj.org-article:b775225155e84a5488bf618023fb3c562021-12-02T15:15:04ZAge-related demethylation of the TDP-43 autoregulatory region in the human motor cortex10.1038/s42003-021-02621-02399-3642https://doaj.org/article/b775225155e84a5488bf618023fb3c562021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02621-0https://doaj.org/toc/2399-3642In order to assess the effects of aging on the autoregulation of TAR DNA-binding protein 43 (TDP-43) and the potential effects of this on the role of TDP-43 in Amyotrophic Lateral Sclerosis (ALS), Koike et al examined post-mortem motor cortex tissue from ALS patients. They found that DNA demethylation in the autoregulatory region of the TARDBP 3′UTR, which encodes TDP-43, increased with age and was associated with the onset age of ALS and thus could be indicative of a role for dysregulation of TDP-43 autoregulation in ALS pathology.Yuka KoikeAkihiro SugaiNorikazu HaraJunko ItoAkio YokosekiTomohiko IshiharaTakuma YamagishiShintaro TsuboguchiMari TadaTakeshi IkeuchiAkiyoshi KakitaOsamu OnoderaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yuka Koike Akihiro Sugai Norikazu Hara Junko Ito Akio Yokoseki Tomohiko Ishihara Takuma Yamagishi Shintaro Tsuboguchi Mari Tada Takeshi Ikeuchi Akiyoshi Kakita Osamu Onodera Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
description	In order to assess the effects of aging on the autoregulation of TAR DNA-binding protein 43 (TDP-43) and the potential effects of this on the role of TDP-43 in Amyotrophic Lateral Sclerosis (ALS), Koike et al examined post-mortem motor cortex tissue from ALS patients. They found that DNA demethylation in the autoregulatory region of the TARDBP 3′UTR, which encodes TDP-43, increased with age and was associated with the onset age of ALS and thus could be indicative of a role for dysregulation of TDP-43 autoregulation in ALS pathology.
format	article
author	Yuka Koike Akihiro Sugai Norikazu Hara Junko Ito Akio Yokoseki Tomohiko Ishihara Takuma Yamagishi Shintaro Tsuboguchi Mari Tada Takeshi Ikeuchi Akiyoshi Kakita Osamu Onodera
author_facet	Yuka Koike Akihiro Sugai Norikazu Hara Junko Ito Akio Yokoseki Tomohiko Ishihara Takuma Yamagishi Shintaro Tsuboguchi Mari Tada Takeshi Ikeuchi Akiyoshi Kakita Osamu Onodera
author_sort	Yuka Koike
title	Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
title_short	Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
title_full	Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
title_fullStr	Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
title_full_unstemmed	Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
title_sort	age-related demethylation of the tdp-43 autoregulatory region in the human motor cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b775225155e84a5488bf618023fb3c56
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Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex

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