Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages
Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development in the mosquito midgut. They suggest that small mo...
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Nature Portfolio
2021
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oai:doaj.org-article:b7773fc630264f8886ca813289e589782021-12-02T17:39:49ZProtein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages10.1038/s42003-021-02273-02399-3642https://doaj.org/article/b7773fc630264f8886ca813289e589782021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02273-0https://doaj.org/toc/2399-3642Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development in the mosquito midgut. They suggest that small molecule inhibitors of PP1 should be explored for blocking parasite transmission.Mohammad ZeeshanRajan PandeyAmit Kumar SubudhiDavid J. P. FergusonGursimran KaurRavish RashpaRaushan NugmanovaDeclan BradyAndrew R. BottrillSue VaughanMathieu BrochetMathieu BollenArnab PainAnthony A. HolderDavid S. GutteryRita TewariNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Mohammad Zeeshan Rajan Pandey Amit Kumar Subudhi David J. P. Ferguson Gursimran Kaur Ravish Rashpa Raushan Nugmanova Declan Brady Andrew R. Bottrill Sue Vaughan Mathieu Brochet Mathieu Bollen Arnab Pain Anthony A. Holder David S. Guttery Rita Tewari Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| description |
Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development in the mosquito midgut. They suggest that small molecule inhibitors of PP1 should be explored for blocking parasite transmission. |
| format |
article |
| author |
Mohammad Zeeshan Rajan Pandey Amit Kumar Subudhi David J. P. Ferguson Gursimran Kaur Ravish Rashpa Raushan Nugmanova Declan Brady Andrew R. Bottrill Sue Vaughan Mathieu Brochet Mathieu Bollen Arnab Pain Anthony A. Holder David S. Guttery Rita Tewari |
| author_facet |
Mohammad Zeeshan Rajan Pandey Amit Kumar Subudhi David J. P. Ferguson Gursimran Kaur Ravish Rashpa Raushan Nugmanova Declan Brady Andrew R. Bottrill Sue Vaughan Mathieu Brochet Mathieu Bollen Arnab Pain Anthony A. Holder David S. Guttery Rita Tewari |
| author_sort |
Mohammad Zeeshan |
| title |
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| title_short |
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| title_full |
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| title_fullStr |
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| title_full_unstemmed |
Protein phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages |
| title_sort |
protein phosphatase 1 regulates atypical mitotic and meiotic division in plasmodium sexual stages |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b7773fc630264f8886ca813289e58978 |
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