Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag

We used time-restricted feeding (TRF) to investigate whether microbial metabolites and the hunger hormone ghrelin can become the dominant entraining factor during chronic jetlag to prevent disruption of the master and peripheral clocks, in order to promote health. Therefore, hypothalamic clock gene...

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Auteurs principaux:	Louis Desmet, Theo Thijs, Rosalie Mas, Kristin Verbeke, Inge Depoortere
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	chronic jetlag circadian clock ghrelin short-chain fatty acids time-restricted feeding Nutrition. Foods and food supply TX341-641
Accès en ligne:	https://doaj.org/article/b7788fd3c3044afc867b0ab7d1d65e41
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spelling	oai:doaj.org-article:b7788fd3c3044afc867b0ab7d1d65e412021-11-25T18:34:36ZTime-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag10.3390/nu131138462072-6643https://doaj.org/article/b7788fd3c3044afc867b0ab7d1d65e412021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3846https://doaj.org/toc/2072-6643We used time-restricted feeding (TRF) to investigate whether microbial metabolites and the hunger hormone ghrelin can become the dominant entraining factor during chronic jetlag to prevent disruption of the master and peripheral clocks, in order to promote health. Therefore, hypothalamic clock gene and <i>Agrp/Npy</i> mRNA expression were measured in mice that were either chronically jetlagged and fed ad libitum, jetlagged and fed a TRF diet, or not jetlagged and fed a TRF diet. Fecal short-chain fatty acid (SCFA) concentrations, plasma ghrelin and corticosterone levels, and colonic clock gene mRNA expression were measured. Preventing the disruption of the food intake pattern during chronic jetlag using TRF restored the rhythmicity in hypothalamic clock gene mRNA expression of <i>Reverbα</i> but not of <i>Arntl</i>. TRF countered the changes in plasma ghrelin levels and in hypothalamic <i>Npy</i> mRNA expression induced by chronic jetlag, thereby reestablishing the food intake pattern. Increase in body mass induced by chronic jetlag was prevented. Alterations in diurnal fluctuations in fecal SCFAs during chronic jetlag were prevented thereby re-entraining the rhythmic expression of peripheral clock genes. In conclusion, TRF during chronodisruption re-entrains the rhythms in clock gene expression and signals from the gut that regulate food intake to normalize body homeostasis.Louis DesmetTheo ThijsRosalie MasKristin VerbekeInge DepoortereMDPI AGarticlechronic jetlagcircadian clockghrelinshort-chain fatty acidstime-restricted feedingNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3846, p 3846 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic jetlag circadian clock ghrelin short-chain fatty acids time-restricted feeding Nutrition. Foods and food supply TX341-641
spellingShingle	chronic jetlag circadian clock ghrelin short-chain fatty acids time-restricted feeding Nutrition. Foods and food supply TX341-641 Louis Desmet Theo Thijs Rosalie Mas Kristin Verbeke Inge Depoortere Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
description	We used time-restricted feeding (TRF) to investigate whether microbial metabolites and the hunger hormone ghrelin can become the dominant entraining factor during chronic jetlag to prevent disruption of the master and peripheral clocks, in order to promote health. Therefore, hypothalamic clock gene and <i>Agrp/Npy</i> mRNA expression were measured in mice that were either chronically jetlagged and fed ad libitum, jetlagged and fed a TRF diet, or not jetlagged and fed a TRF diet. Fecal short-chain fatty acid (SCFA) concentrations, plasma ghrelin and corticosterone levels, and colonic clock gene mRNA expression were measured. Preventing the disruption of the food intake pattern during chronic jetlag using TRF restored the rhythmicity in hypothalamic clock gene mRNA expression of <i>Reverbα</i> but not of <i>Arntl</i>. TRF countered the changes in plasma ghrelin levels and in hypothalamic <i>Npy</i> mRNA expression induced by chronic jetlag, thereby reestablishing the food intake pattern. Increase in body mass induced by chronic jetlag was prevented. Alterations in diurnal fluctuations in fecal SCFAs during chronic jetlag were prevented thereby re-entraining the rhythmic expression of peripheral clock genes. In conclusion, TRF during chronodisruption re-entrains the rhythms in clock gene expression and signals from the gut that regulate food intake to normalize body homeostasis.
format	article
author	Louis Desmet Theo Thijs Rosalie Mas Kristin Verbeke Inge Depoortere
author_facet	Louis Desmet Theo Thijs Rosalie Mas Kristin Verbeke Inge Depoortere
author_sort	Louis Desmet
title	Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
title_short	Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
title_full	Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
title_fullStr	Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
title_full_unstemmed	Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
title_sort	time-restricted feeding in mice prevents the disruption of the peripheral circadian clocks and its metabolic impact during chronic jetlag
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b7788fd3c3044afc867b0ab7d1d65e41
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Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag

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