Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review

The last decade has witnessed tremendous growth in tocotrienols (T3s) research, especially in the field of oncology, owing to potent anticancer property. Among the many types of cancers, colorectal cancer (CRC) is growing to become a serious global health threat to humans. Chemoprevention strategies...

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Autores principales:	Ali Qusay Khalid, Saatheeyavaane Bhuvanendran, Kasthuri Bai Magalingam, Premdass Ramdas, Mangala Kumari, Ammu Kutty Radhakrishnan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin E tocotrienols colorectal cancer cell lines biomarkers Cytoscape Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b778b124e8474d21b39961846535cfc1
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spelling	oai:doaj.org-article:b778b124e8474d21b39961846535cfc12021-11-25T18:36:26ZClinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review10.3390/nu131140562072-6643https://doaj.org/article/b778b124e8474d21b39961846535cfc12021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4056https://doaj.org/toc/2072-6643The last decade has witnessed tremendous growth in tocotrienols (T3s) research, especially in the field of oncology, owing to potent anticancer property. Among the many types of cancers, colorectal cancer (CRC) is growing to become a serious global health threat to humans. Chemoprevention strategies in recent days are open to exploring alternative interventions to inhibit or delay carcinogenesis, especially with the use of bioactive natural compounds, such as tocotrienols. This scoping review aims to distil the large bodies of literature from various databases to identify the genes and their encoded modulations by tocotrienols and to explicate important mechanisms via which T3s combat CRC. For this scoping review, research papers published from 2010 to early 2021 related to T3s and human CRC cells were reviewed in compliance with the PRISMA guidelines. The study included research articles published in English, searchable on four literature databases (Ovid MEDLINE, PubMed, Scopus, and Embase) that reported differential expression of genes and proteins in human CRC cell lines following exposure to T3s. A total of 12 articles that fulfilled the inclusion and exclusion criteria of the study were short-listed for data extraction and analysis. The results from the analysis of these 12 articles showed that T3s, especially its γ and δ analogues, modulated the expression of 16 genes and their encoded proteins that are associated with several important CRC pathways (apoptosis, transcriptional dysregulation in cancer, and cancer progression). Further studies and validation work are required to scrutinize the specific role of T3s on these genes and proteins and to propose the use of T3s to develop adjuvant or multi-targeted therapy for CRC.Ali Qusay KhalidSaatheeyavaane BhuvanendranKasthuri Bai MagalingamPremdass RamdasMangala KumariAmmu Kutty RadhakrishnanMDPI AGarticlevitamin Etocotrienolscolorectal cancercell linesbiomarkersCytoscapeNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4056, p 4056 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin E tocotrienols colorectal cancer cell lines biomarkers Cytoscape Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin E tocotrienols colorectal cancer cell lines biomarkers Cytoscape Nutrition. Foods and food supply TX341-641 Ali Qusay Khalid Saatheeyavaane Bhuvanendran Kasthuri Bai Magalingam Premdass Ramdas Mangala Kumari Ammu Kutty Radhakrishnan Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
description	The last decade has witnessed tremendous growth in tocotrienols (T3s) research, especially in the field of oncology, owing to potent anticancer property. Among the many types of cancers, colorectal cancer (CRC) is growing to become a serious global health threat to humans. Chemoprevention strategies in recent days are open to exploring alternative interventions to inhibit or delay carcinogenesis, especially with the use of bioactive natural compounds, such as tocotrienols. This scoping review aims to distil the large bodies of literature from various databases to identify the genes and their encoded modulations by tocotrienols and to explicate important mechanisms via which T3s combat CRC. For this scoping review, research papers published from 2010 to early 2021 related to T3s and human CRC cells were reviewed in compliance with the PRISMA guidelines. The study included research articles published in English, searchable on four literature databases (Ovid MEDLINE, PubMed, Scopus, and Embase) that reported differential expression of genes and proteins in human CRC cell lines following exposure to T3s. A total of 12 articles that fulfilled the inclusion and exclusion criteria of the study were short-listed for data extraction and analysis. The results from the analysis of these 12 articles showed that T3s, especially its γ and δ analogues, modulated the expression of 16 genes and their encoded proteins that are associated with several important CRC pathways (apoptosis, transcriptional dysregulation in cancer, and cancer progression). Further studies and validation work are required to scrutinize the specific role of T3s on these genes and proteins and to propose the use of T3s to develop adjuvant or multi-targeted therapy for CRC.
format	article
author	Ali Qusay Khalid Saatheeyavaane Bhuvanendran Kasthuri Bai Magalingam Premdass Ramdas Mangala Kumari Ammu Kutty Radhakrishnan
author_facet	Ali Qusay Khalid Saatheeyavaane Bhuvanendran Kasthuri Bai Magalingam Premdass Ramdas Mangala Kumari Ammu Kutty Radhakrishnan
author_sort	Ali Qusay Khalid
title	Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
title_short	Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
title_full	Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
title_fullStr	Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
title_full_unstemmed	Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review
title_sort	clinically relevant genes and proteins modulated by tocotrienols in human colon cancer cell lines: systematic scoping review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b778b124e8474d21b39961846535cfc1
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Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review

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