Divergent connectomic organization delineates genetic evolutionary traits in the human brain

Abstract The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and di...

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Autores principales:	Elisenda Bueichekú, Jose M. Gonzalez-de-Echavarri, Laura Ortiz-Teran, Victor Montal, Federico d’Oleire Uquillas, Lola De Marcos, William Orwig, Chan-Mi Kim, Elena Ortiz-Teran, Silvia Basaia, Ibai Diez, Jorge Sepulcre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b77a2889ddd64746ab39110f7f8fb449
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spelling	oai:doaj.org-article:b77a2889ddd64746ab39110f7f8fb4492021-12-02T19:16:18ZDivergent connectomic organization delineates genetic evolutionary traits in the human brain10.1038/s41598-021-99082-62045-2322https://doaj.org/article/b77a2889ddd64746ab39110f7f8fb4492021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99082-6https://doaj.org/toc/2045-2322Abstract The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities—linked to Neuron Projection—were overrepresented cell traits. Homologue-orthologue comparisons using dN/dS-ratios bridged the gap between neurogenetic outcomes and biological data, summarizing the known evolutionary divergent pathways within the Homo Sapiens lineage. Evidence suggests that a crosstalk between functional specialization and information flow reflects putative biological qualities of brain architecture, such as neurite cellular functions like axonal or dendrite processes, hypothesized to have been selectively conserved in the species through positive selection. These findings expand our understanding of human brain function and unveil aspects of our cognitive trajectory in relation to our simian ancestors previously left unexplored.Elisenda BueichekúJose M. Gonzalez-de-EchavarriLaura Ortiz-TeranVictor MontalFederico d’Oleire UquillasLola De MarcosWilliam OrwigChan-Mi KimElena Ortiz-TeranSilvia BasaiaIbai DiezJorge SepulcreNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisenda Bueichekú Jose M. Gonzalez-de-Echavarri Laura Ortiz-Teran Victor Montal Federico d’Oleire Uquillas Lola De Marcos William Orwig Chan-Mi Kim Elena Ortiz-Teran Silvia Basaia Ibai Diez Jorge Sepulcre Divergent connectomic organization delineates genetic evolutionary traits in the human brain
description	Abstract The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities—linked to Neuron Projection—were overrepresented cell traits. Homologue-orthologue comparisons using dN/dS-ratios bridged the gap between neurogenetic outcomes and biological data, summarizing the known evolutionary divergent pathways within the Homo Sapiens lineage. Evidence suggests that a crosstalk between functional specialization and information flow reflects putative biological qualities of brain architecture, such as neurite cellular functions like axonal or dendrite processes, hypothesized to have been selectively conserved in the species through positive selection. These findings expand our understanding of human brain function and unveil aspects of our cognitive trajectory in relation to our simian ancestors previously left unexplored.
format	article
author	Elisenda Bueichekú Jose M. Gonzalez-de-Echavarri Laura Ortiz-Teran Victor Montal Federico d’Oleire Uquillas Lola De Marcos William Orwig Chan-Mi Kim Elena Ortiz-Teran Silvia Basaia Ibai Diez Jorge Sepulcre
author_facet	Elisenda Bueichekú Jose M. Gonzalez-de-Echavarri Laura Ortiz-Teran Victor Montal Federico d’Oleire Uquillas Lola De Marcos William Orwig Chan-Mi Kim Elena Ortiz-Teran Silvia Basaia Ibai Diez Jorge Sepulcre
author_sort	Elisenda Bueichekú
title	Divergent connectomic organization delineates genetic evolutionary traits in the human brain
title_short	Divergent connectomic organization delineates genetic evolutionary traits in the human brain
title_full	Divergent connectomic organization delineates genetic evolutionary traits in the human brain
title_fullStr	Divergent connectomic organization delineates genetic evolutionary traits in the human brain
title_full_unstemmed	Divergent connectomic organization delineates genetic evolutionary traits in the human brain
title_sort	divergent connectomic organization delineates genetic evolutionary traits in the human brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b77a2889ddd64746ab39110f7f8fb449
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Divergent connectomic organization delineates genetic evolutionary traits in the human brain

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