Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.

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Autores principales:	Arianna Pocaterra, Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen, Matthias Evert, Diego F. Calvisi, Sirio Dupont
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b7806795bac144798bc500c28e43add1
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spelling	oai:doaj.org-article:b7806795bac144798bc500c28e43add12021-12-02T16:05:53ZFascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development10.1038/s42003-021-02286-92399-3642https://doaj.org/article/b7806795bac144798bc500c28e43add12021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02286-9https://doaj.org/toc/2399-3642Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.Arianna PocaterraGloria ScattolinPatrizia RomaniCindy AmentSilvia RibbackXin ChenMatthias EvertDiego F. CalvisiSirio DupontNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Arianna Pocaterra Gloria Scattolin Patrizia Romani Cindy Ament Silvia Ribback Xin Chen Matthias Evert Diego F. Calvisi Sirio Dupont Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
description	Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.
format	article
author	Arianna Pocaterra Gloria Scattolin Patrizia Romani Cindy Ament Silvia Ribback Xin Chen Matthias Evert Diego F. Calvisi Sirio Dupont
author_facet	Arianna Pocaterra Gloria Scattolin Patrizia Romani Cindy Ament Silvia Ribback Xin Chen Matthias Evert Diego F. Calvisi Sirio Dupont
author_sort	Arianna Pocaterra
title	Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
title_short	Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
title_full	Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
title_fullStr	Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
title_full_unstemmed	Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development
title_sort	fascin1 empowers yap mechanotransduction and promotes cholangiocarcinoma development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7806795bac144798bc500c28e43add1
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Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

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