Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.

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Detalles Bibliográficos
Autores principales: Arianna Pocaterra, Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen, Matthias Evert, Diego F. Calvisi, Sirio Dupont
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/b7806795bac144798bc500c28e43add1
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