Harmful R-loops are prevented via different cell cycle-specific mechanisms

Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a major mechanism being independent of replication...

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Autores principales:	Marta San Martin-Alonso, María E. Soler-Oliva, María García-Rubio, Tatiana García-Muse, Andrés Aguilera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b783d30442df48748c1102cb0f8b0a58
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spelling	oai:doaj.org-article:b783d30442df48748c1102cb0f8b0a582021-12-02T16:43:31ZHarmful R-loops are prevented via different cell cycle-specific mechanisms10.1038/s41467-021-24737-x2041-1723https://doaj.org/article/b783d30442df48748c1102cb0f8b0a582021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24737-xhttps://doaj.org/toc/2041-1723Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a major mechanism being independent of replication and another one being linked to replication.Marta San Martin-AlonsoMaría E. Soler-OlivaMaría García-RubioTatiana García-MuseAndrés AguileraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta San Martin-Alonso María E. Soler-Oliva María García-Rubio Tatiana García-Muse Andrés Aguilera Harmful R-loops are prevented via different cell cycle-specific mechanisms
description	Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a major mechanism being independent of replication and another one being linked to replication.
format	article
author	Marta San Martin-Alonso María E. Soler-Oliva María García-Rubio Tatiana García-Muse Andrés Aguilera
author_facet	Marta San Martin-Alonso María E. Soler-Oliva María García-Rubio Tatiana García-Muse Andrés Aguilera
author_sort	Marta San Martin-Alonso
title	Harmful R-loops are prevented via different cell cycle-specific mechanisms
title_short	Harmful R-loops are prevented via different cell cycle-specific mechanisms
title_full	Harmful R-loops are prevented via different cell cycle-specific mechanisms
title_fullStr	Harmful R-loops are prevented via different cell cycle-specific mechanisms
title_full_unstemmed	Harmful R-loops are prevented via different cell cycle-specific mechanisms
title_sort	harmful r-loops are prevented via different cell cycle-specific mechanisms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b783d30442df48748c1102cb0f8b0a58
work_keys_str_mv	AT martasanmartinalonso harmfulrloopsarepreventedviadifferentcellcyclespecificmechanisms AT mariaesoleroliva harmfulrloopsarepreventedviadifferentcellcyclespecificmechanisms AT mariagarciarubio harmfulrloopsarepreventedviadifferentcellcyclespecificmechanisms AT tatianagarciamuse harmfulrloopsarepreventedviadifferentcellcyclespecificmechanisms AT andresaguilera harmfulrloopsarepreventedviadifferentcellcyclespecificmechanisms
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Harmful R-loops are prevented via different cell cycle-specific mechanisms

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