Stability and dynamics of membrane-spanning DNA nanopores

Although DNA nanopores are widely explored as synthetic membrane proteins, it is still unclear how the anionic DNA assemblies stably reside within the hydrophobic core of a lipid bilayer. Here, the authors use molecular dynamics simulations to reveal the key dynamic interactions and energetics stabi...

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Autores principales:	Vishal Maingi, Jonathan R. Burns, Jaakko J. Uusitalo, Stefan Howorka, Siewert J. Marrink, Mark S. P. Sansom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b785a04b11934e5fa7e46990ee5a6991
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id	oai:doaj.org-article:b785a04b11934e5fa7e46990ee5a6991
record_format	dspace
spelling	oai:doaj.org-article:b785a04b11934e5fa7e46990ee5a69912021-12-02T14:40:36ZStability and dynamics of membrane-spanning DNA nanopores10.1038/ncomms147842041-1723https://doaj.org/article/b785a04b11934e5fa7e46990ee5a69912017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14784https://doaj.org/toc/2041-1723Although DNA nanopores are widely explored as synthetic membrane proteins, it is still unclear how the anionic DNA assemblies stably reside within the hydrophobic core of a lipid bilayer. Here, the authors use molecular dynamics simulations to reveal the key dynamic interactions and energetics stabilizing the nanopore-membrane interaction.Vishal MaingiJonathan R. BurnsJaakko J. UusitaloStefan HoworkaSiewert J. MarrinkMark S. P. SansomNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vishal Maingi Jonathan R. Burns Jaakko J. Uusitalo Stefan Howorka Siewert J. Marrink Mark S. P. Sansom Stability and dynamics of membrane-spanning DNA nanopores
description	Although DNA nanopores are widely explored as synthetic membrane proteins, it is still unclear how the anionic DNA assemblies stably reside within the hydrophobic core of a lipid bilayer. Here, the authors use molecular dynamics simulations to reveal the key dynamic interactions and energetics stabilizing the nanopore-membrane interaction.
format	article
author	Vishal Maingi Jonathan R. Burns Jaakko J. Uusitalo Stefan Howorka Siewert J. Marrink Mark S. P. Sansom
author_facet	Vishal Maingi Jonathan R. Burns Jaakko J. Uusitalo Stefan Howorka Siewert J. Marrink Mark S. P. Sansom
author_sort	Vishal Maingi
title	Stability and dynamics of membrane-spanning DNA nanopores
title_short	Stability and dynamics of membrane-spanning DNA nanopores
title_full	Stability and dynamics of membrane-spanning DNA nanopores
title_fullStr	Stability and dynamics of membrane-spanning DNA nanopores
title_full_unstemmed	Stability and dynamics of membrane-spanning DNA nanopores
title_sort	stability and dynamics of membrane-spanning dna nanopores
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b785a04b11934e5fa7e46990ee5a6991
work_keys_str_mv	AT vishalmaingi stabilityanddynamicsofmembranespanningdnananopores AT jonathanrburns stabilityanddynamicsofmembranespanningdnananopores AT jaakkojuusitalo stabilityanddynamicsofmembranespanningdnananopores AT stefanhoworka stabilityanddynamicsofmembranespanningdnananopores AT siewertjmarrink stabilityanddynamicsofmembranespanningdnananopores AT markspsansom stabilityanddynamicsofmembranespanningdnananopores
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Stability and dynamics of membrane-spanning DNA nanopores

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