Stability and dynamics of membrane-spanning DNA nanopores

Although DNA nanopores are widely explored as synthetic membrane proteins, it is still unclear how the anionic DNA assemblies stably reside within the hydrophobic core of a lipid bilayer. Here, the authors use molecular dynamics simulations to reveal the key dynamic interactions and energetics stabi...

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Bibliographic Details
Main Authors: Vishal Maingi, Jonathan R. Burns, Jaakko J. Uusitalo, Stefan Howorka, Siewert J. Marrink, Mark S. P. Sansom
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/b785a04b11934e5fa7e46990ee5a6991
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