Selective BET bromodomain inhibition as an antifungal therapeutic strategy

BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogenCandida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs...

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Autores principales:	Flore Mietton, Elena Ferri, Morgane Champleboux, Ninon Zala, Danièle Maubon, Yingsheng Zhou, Mike Harbut, Didier Spittler, Cécile Garnaud, Marie Courçon, Murielle Chauvel, Christophe d’Enfert, Boris A. Kashemirov, Mitchell Hull, Muriel Cornet, Charles E. McKenna, Jérôme Govin, Carlo Petosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b785e8e41a984029a993b4d097ddeb4e
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spelling	oai:doaj.org-article:b785e8e41a984029a993b4d097ddeb4e2021-12-02T15:38:32ZSelective BET bromodomain inhibition as an antifungal therapeutic strategy10.1038/ncomms154822041-1723https://doaj.org/article/b785e8e41a984029a993b4d097ddeb4e2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15482https://doaj.org/toc/2041-1723BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogenCandida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs.Flore MiettonElena FerriMorgane ChamplebouxNinon ZalaDanièle MaubonYingsheng ZhouMike HarbutDidier SpittlerCécile GarnaudMarie CourçonMurielle ChauvelChristophe d’EnfertBoris A. KashemirovMitchell HullMuriel CornetCharles E. McKennaJérôme GovinCarlo PetosaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Flore Mietton Elena Ferri Morgane Champleboux Ninon Zala Danièle Maubon Yingsheng Zhou Mike Harbut Didier Spittler Cécile Garnaud Marie Courçon Murielle Chauvel Christophe d’Enfert Boris A. Kashemirov Mitchell Hull Muriel Cornet Charles E. McKenna Jérôme Govin Carlo Petosa Selective BET bromodomain inhibition as an antifungal therapeutic strategy
description	BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogenCandida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs.
format	article
author	Flore Mietton Elena Ferri Morgane Champleboux Ninon Zala Danièle Maubon Yingsheng Zhou Mike Harbut Didier Spittler Cécile Garnaud Marie Courçon Murielle Chauvel Christophe d’Enfert Boris A. Kashemirov Mitchell Hull Muriel Cornet Charles E. McKenna Jérôme Govin Carlo Petosa
author_facet	Flore Mietton Elena Ferri Morgane Champleboux Ninon Zala Danièle Maubon Yingsheng Zhou Mike Harbut Didier Spittler Cécile Garnaud Marie Courçon Murielle Chauvel Christophe d’Enfert Boris A. Kashemirov Mitchell Hull Muriel Cornet Charles E. McKenna Jérôme Govin Carlo Petosa
author_sort	Flore Mietton
title	Selective BET bromodomain inhibition as an antifungal therapeutic strategy
title_short	Selective BET bromodomain inhibition as an antifungal therapeutic strategy
title_full	Selective BET bromodomain inhibition as an antifungal therapeutic strategy
title_fullStr	Selective BET bromodomain inhibition as an antifungal therapeutic strategy
title_full_unstemmed	Selective BET bromodomain inhibition as an antifungal therapeutic strategy
title_sort	selective bet bromodomain inhibition as an antifungal therapeutic strategy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b785e8e41a984029a993b4d097ddeb4e
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Selective BET bromodomain inhibition as an antifungal therapeutic strategy

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