Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma.

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Bibliographic Details
Main Authors:	Fang Sun, Hsiang-Chieh Hung, Andrew Sinclair, Peng Zhang, Tao Bai, Daniel David Galvan, Priyesh Jain, Bowen Li, Shaoyi Jiang, Qiuming Yu
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/b78697f9b95a451c8e56f154160ba36f
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spelling	oai:doaj.org-article:b78697f9b95a451c8e56f154160ba36f2021-12-02T14:38:56ZHierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma10.1038/ncomms134372041-1723https://doaj.org/article/b78697f9b95a451c8e56f154160ba36f2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13437https://doaj.org/toc/2041-1723Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma.Fang SunHsiang-Chieh HungAndrew SinclairPeng ZhangTao BaiDaniel David GalvanPriyesh JainBowen LiShaoyi JiangQiuming YuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fang Sun Hsiang-Chieh Hung Andrew Sinclair Peng Zhang Tao Bai Daniel David Galvan Priyesh Jain Bowen Li Shaoyi Jiang Qiuming Yu Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
description	Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma.
format	article
author	Fang Sun Hsiang-Chieh Hung Andrew Sinclair Peng Zhang Tao Bai Daniel David Galvan Priyesh Jain Bowen Li Shaoyi Jiang Qiuming Yu
author_facet	Fang Sun Hsiang-Chieh Hung Andrew Sinclair Peng Zhang Tao Bai Daniel David Galvan Priyesh Jain Bowen Li Shaoyi Jiang Qiuming Yu
author_sort	Fang Sun
title	Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
title_short	Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
title_full	Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
title_fullStr	Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
title_full_unstemmed	Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
title_sort	hierarchical zwitterionic modification of a sers substrate enables real-time drug monitoring in blood plasma
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b78697f9b95a451c8e56f154160ba36f
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_version_	1718390792083472384

Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

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