VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a channel-like chloride conductance.

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Autores principales:	Magalie Martineau, Raul E. Guzman, Christoph Fahlke, Jürgen Klingauf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b786f7fd06784ed9b2dc81d26ce81d9b
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spelling	oai:doaj.org-article:b786f7fd06784ed9b2dc81d26ce81d9b2021-12-02T14:40:56ZVGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses10.1038/s41467-017-02367-62041-1723https://doaj.org/article/b786f7fd06784ed9b2dc81d26ce81d9b2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02367-6https://doaj.org/toc/2041-1723During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a channel-like chloride conductance.Magalie MartineauRaul E. GuzmanChristoph FahlkeJürgen KlingaufNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magalie Martineau Raul E. Guzman Christoph Fahlke Jürgen Klingauf VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
description	During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a channel-like chloride conductance.
format	article
author	Magalie Martineau Raul E. Guzman Christoph Fahlke Jürgen Klingauf
author_facet	Magalie Martineau Raul E. Guzman Christoph Fahlke Jürgen Klingauf
author_sort	Magalie Martineau
title	VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
title_short	VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
title_full	VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
title_fullStr	VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
title_full_unstemmed	VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
title_sort	vglut1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b786f7fd06784ed9b2dc81d26ce81d9b
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VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

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