Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema

Abstract We aimed to investigate the clinical implication of suspended scattering particles in motion (SSPiM) using optical coherence tomography angiography (OCTA) among branch retinal vein occlusion disease (BRVO) cases with macular edema (ME). Medical records of BRVO patients were reviewed. Centra...

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Autores principales:	Kwang-Eon Choi, Sangheon Han, Cheolmin Yun, Seong-Woo Kim, Jaeryung Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b78823690f3947eaa470a79a251ad345
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spelling	oai:doaj.org-article:b78823690f3947eaa470a79a251ad3452021-12-02T16:45:46ZSuspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema10.1038/s41598-020-70784-72045-2322https://doaj.org/article/b78823690f3947eaa470a79a251ad3452020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70784-7https://doaj.org/toc/2045-2322Abstract We aimed to investigate the clinical implication of suspended scattering particles in motion (SSPiM) using optical coherence tomography angiography (OCTA) among branch retinal vein occlusion disease (BRVO) cases with macular edema (ME). Medical records of BRVO patients were reviewed. Central retinal thickness (CRT), ME type, and cyst size on optical coherence tomography images were evaluated before and after intravitreal bevacizumab injection. Nonperfusion area, SSPiM, and microvascular abnormalities in OCTA images were evaluated using a Heidelberg machine. SSPiM was identified in 24 of 56 cases. There were no differences in baseline characteristics between groups with and without SSPiM. Disease duration, disease-free duration, previous injection number, microaneurysms in the superficial vascular complex, and microaneurysms in the deep vascular complex (DVC) (p = 0.003, 0.013, 0.028, 0.003, < 0.001, respectively) differed significantly between the two groups. After multivariate logistic analysis, microaneurysms in the DVC were the only different factor between the two groups (odds ratio [OR]: 0.091; p = 0.001). Furthermore, SSPiM in the DVC (OR 10.908; p = 0.002) and nonperfusion grade (OR 0.039; p < 0.001) were significantly associated with cyst response after intravitreal injection. SSPiM may be correlated with microaneurysms in the DVC and a poor anatomical response after intravitreal injection.Kwang-Eon ChoiSangheon HanCheolmin YunSeong-Woo KimJaeryung OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kwang-Eon Choi Sangheon Han Cheolmin Yun Seong-Woo Kim Jaeryung Oh Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
description	Abstract We aimed to investigate the clinical implication of suspended scattering particles in motion (SSPiM) using optical coherence tomography angiography (OCTA) among branch retinal vein occlusion disease (BRVO) cases with macular edema (ME). Medical records of BRVO patients were reviewed. Central retinal thickness (CRT), ME type, and cyst size on optical coherence tomography images were evaluated before and after intravitreal bevacizumab injection. Nonperfusion area, SSPiM, and microvascular abnormalities in OCTA images were evaluated using a Heidelberg machine. SSPiM was identified in 24 of 56 cases. There were no differences in baseline characteristics between groups with and without SSPiM. Disease duration, disease-free duration, previous injection number, microaneurysms in the superficial vascular complex, and microaneurysms in the deep vascular complex (DVC) (p = 0.003, 0.013, 0.028, 0.003, < 0.001, respectively) differed significantly between the two groups. After multivariate logistic analysis, microaneurysms in the DVC were the only different factor between the two groups (odds ratio [OR]: 0.091; p = 0.001). Furthermore, SSPiM in the DVC (OR 10.908; p = 0.002) and nonperfusion grade (OR 0.039; p < 0.001) were significantly associated with cyst response after intravitreal injection. SSPiM may be correlated with microaneurysms in the DVC and a poor anatomical response after intravitreal injection.
format	article
author	Kwang-Eon Choi Sangheon Han Cheolmin Yun Seong-Woo Kim Jaeryung Oh
author_facet	Kwang-Eon Choi Sangheon Han Cheolmin Yun Seong-Woo Kim Jaeryung Oh
author_sort	Kwang-Eon Choi
title	Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
title_short	Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
title_full	Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
title_fullStr	Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
title_full_unstemmed	Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema
title_sort	suspended scattering particles in motion using oct angiography in branch retinal vein occlusion disease cases with cystoid macular edema
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b78823690f3947eaa470a79a251ad345
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Suspended scattering particles in motion using OCT angiography in branch retinal vein occlusion disease cases with cystoid macular edema

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