The Effects of Vitamin D on Immune System and Inflammatory Diseases

Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a signifi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomoka Ao, Junichi Kikuta, Masaru Ishii
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin D immune system COVID-19 rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) multiple sclerosis (MS) Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b78c43dc8ced4bbb824ad39b769cad85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b78c43dc8ced4bbb824ad39b769cad85
record_format	dspace
spelling	oai:doaj.org-article:b78c43dc8ced4bbb824ad39b769cad852021-11-25T16:52:54ZThe Effects of Vitamin D on Immune System and Inflammatory Diseases10.3390/biom111116242218-273Xhttps://doaj.org/article/b78c43dc8ced4bbb824ad39b769cad852021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1624https://doaj.org/toc/2218-273XImmune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the impact of vitamin D on treatment and prevention, particularly in infectious diseases such as the 2019 coronavirus disease (COVID-19), remains controversial. Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D.Tomoka AoJunichi KikutaMasaru IshiiMDPI AGarticlevitamin Dimmune systemCOVID-19rheumatoid arthritis (RA)systemic lupus erythematosus (SLE)multiple sclerosis (MS)MicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1624, p 1624 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D immune system COVID-19 rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) multiple sclerosis (MS) Microbiology QR1-502
spellingShingle	vitamin D immune system COVID-19 rheumatoid arthritis (RA) systemic lupus erythematosus (SLE) multiple sclerosis (MS) Microbiology QR1-502 Tomoka Ao Junichi Kikuta Masaru Ishii The Effects of Vitamin D on Immune System and Inflammatory Diseases
description	Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. However, the impact of vitamin D on treatment and prevention, particularly in infectious diseases such as the 2019 coronavirus disease (COVID-19), remains controversial. Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D.
format	article
author	Tomoka Ao Junichi Kikuta Masaru Ishii
author_facet	Tomoka Ao Junichi Kikuta Masaru Ishii
author_sort	Tomoka Ao
title	The Effects of Vitamin D on Immune System and Inflammatory Diseases
title_short	The Effects of Vitamin D on Immune System and Inflammatory Diseases
title_full	The Effects of Vitamin D on Immune System and Inflammatory Diseases
title_fullStr	The Effects of Vitamin D on Immune System and Inflammatory Diseases
title_full_unstemmed	The Effects of Vitamin D on Immune System and Inflammatory Diseases
title_sort	effects of vitamin d on immune system and inflammatory diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b78c43dc8ced4bbb824ad39b769cad85
work_keys_str_mv	AT tomokaao theeffectsofvitamindonimmunesystemandinflammatorydiseases AT junichikikuta theeffectsofvitamindonimmunesystemandinflammatorydiseases AT masaruishii theeffectsofvitamindonimmunesystemandinflammatorydiseases AT tomokaao effectsofvitamindonimmunesystemandinflammatorydiseases AT junichikikuta effectsofvitamindonimmunesystemandinflammatorydiseases AT masaruishii effectsofvitamindonimmunesystemandinflammatorydiseases
_version_	1718412917824552960

The Effects of Vitamin D on Immune System and Inflammatory Diseases

Ejemplares similares