Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

Abstract Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS)...

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Autores principales:	Javier Escudero, Victoria Heredia-Soto, Yinyin Wang, Patricia Ruiz, Yingying Hu, Alejandro Gallego, Jose Juan Pozo-Kreilinger, Virginia Martinez-Marin, Alberto Berjon, Eduardo Ortiz-Cruz, Daniel Bernabeu, Jaime Feliu, Jing Tang, Andres Redondo, Marta Mendiola
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/b78e4f4455e240a4918e698b421f1608
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spelling	oai:doaj.org-article:b78e4f4455e240a4918e698b421f16082021-12-05T12:23:42ZEribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?10.1186/s12935-021-02337-51475-2867https://doaj.org/article/b78e4f4455e240a4918e698b421f16082021-12-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02337-5https://doaj.org/toc/1475-2867Abstract Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D) spheroid cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest, for the first time, a synergistic effect with ifosfamide in all models, and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.Javier EscuderoVictoria Heredia-SotoYinyin WangPatricia RuizYingying HuAlejandro GallegoJose Juan Pozo-KreilingerVirginia Martinez-MarinAlberto BerjonEduardo Ortiz-CruzDaniel BernabeuJaime FeliuJing TangAndres RedondoMarta MendiolaBMCarticleEribulinSarcomaProliferationMigrationInvasion2D and 3D modelsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Javier Escudero Victoria Heredia-Soto Yinyin Wang Patricia Ruiz Yingying Hu Alejandro Gallego Jose Juan Pozo-Kreilinger Virginia Martinez-Marin Alberto Berjon Eduardo Ortiz-Cruz Daniel Bernabeu Jaime Feliu Jing Tang Andres Redondo Marta Mendiola Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
description	Abstract Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D) spheroid cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest, for the first time, a synergistic effect with ifosfamide in all models, and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.
format	article
author	Javier Escudero Victoria Heredia-Soto Yinyin Wang Patricia Ruiz Yingying Hu Alejandro Gallego Jose Juan Pozo-Kreilinger Virginia Martinez-Marin Alberto Berjon Eduardo Ortiz-Cruz Daniel Bernabeu Jaime Feliu Jing Tang Andres Redondo Marta Mendiola
author_facet	Javier Escudero Victoria Heredia-Soto Yinyin Wang Patricia Ruiz Yingying Hu Alejandro Gallego Jose Juan Pozo-Kreilinger Virginia Martinez-Marin Alberto Berjon Eduardo Ortiz-Cruz Daniel Bernabeu Jaime Feliu Jing Tang Andres Redondo Marta Mendiola
author_sort	Javier Escudero
title	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_short	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_full	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_fullStr	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_full_unstemmed	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_sort	eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b78e4f4455e240a4918e698b421f1608
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Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

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