GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 replication.
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Nature Portfolio
2021
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oai:doaj.org-article:b7901ebbdbb44f8fa47ee44897662e082021-12-02T14:17:29ZGCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein10.1038/s41467-021-22297-82041-1723https://doaj.org/article/b7901ebbdbb44f8fa47ee44897662e082021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22297-8https://doaj.org/toc/2041-1723Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 replication.Ming ZhaoYu YuLi-Ming SunJia-Qing XingTingting LiYunkai ZhuMiao WangYin YuWen XueTian XiaHong CaiQiu-Ying HanXiaoyao YinWei-Hua LiAi-Ling LiJiuwei CuiZhenghong YuanRong ZhangTao ZhouXue-Min ZhangTao LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ming Zhao Yu Yu Li-Ming Sun Jia-Qing Xing Tingting Li Yunkai Zhu Miao Wang Yin Yu Wen Xue Tian Xia Hong Cai Qiu-Ying Han Xiaoyao Yin Wei-Hua Li Ai-Ling Li Jiuwei Cui Zhenghong Yuan Rong Zhang Tao Zhou Xue-Min Zhang Tao Li GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| description |
Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 replication. |
| format |
article |
| author |
Ming Zhao Yu Yu Li-Ming Sun Jia-Qing Xing Tingting Li Yunkai Zhu Miao Wang Yin Yu Wen Xue Tian Xia Hong Cai Qiu-Ying Han Xiaoyao Yin Wei-Hua Li Ai-Ling Li Jiuwei Cui Zhenghong Yuan Rong Zhang Tao Zhou Xue-Min Zhang Tao Li |
| author_facet |
Ming Zhao Yu Yu Li-Ming Sun Jia-Qing Xing Tingting Li Yunkai Zhu Miao Wang Yin Yu Wen Xue Tian Xia Hong Cai Qiu-Ying Han Xiaoyao Yin Wei-Hua Li Ai-Ling Li Jiuwei Cui Zhenghong Yuan Rong Zhang Tao Zhou Xue-Min Zhang Tao Li |
| author_sort |
Ming Zhao |
| title |
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| title_short |
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| title_full |
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| title_fullStr |
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| title_full_unstemmed |
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| title_sort |
gcg inhibits sars-cov-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b7901ebbdbb44f8fa47ee44897662e08 |
| work_keys_str_mv |
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