Sex difference in the weighting of expected uncertainty under chronic stress

Abstract The neurobiological literature implicates chronic stress induced decision-making deficits as a major contributor to depression and anxiety. Given that females are twice as likely to suffer from these disorders, we hypothesized the existence of sex difference in the effects of chronic stress...

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Autores principales:	Huijie Lei, Yasuhiro Mochizuki, Chong Chen, Kosuke Hagiwara, Masako Hirotsu, Toshio Matsubara, Shin Nakagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b790b6e0691144cfa610f1331b5d73b2
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spelling	oai:doaj.org-article:b790b6e0691144cfa610f1331b5d73b22021-12-02T13:39:34ZSex difference in the weighting of expected uncertainty under chronic stress10.1038/s41598-021-88155-12045-2322https://doaj.org/article/b790b6e0691144cfa610f1331b5d73b22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88155-1https://doaj.org/toc/2045-2322Abstract The neurobiological literature implicates chronic stress induced decision-making deficits as a major contributor to depression and anxiety. Given that females are twice as likely to suffer from these disorders, we hypothesized the existence of sex difference in the effects of chronic stress on decision-making. Here employing a decision-making paradigm that relies on reinforcement learning of probabilistic predictive relationships, we show female volunteers with a high level of perceived stress in the past month are more likely to make suboptimal choices than males. Computational characterizations of this sex difference suggest that while under high stress, females and males differ in their weighting but not learning of the expected uncertainty in the predictive relationships. These findings provide a mechanistic account of the sex difference in decision-making under chronic stress and may have important implications for the epidemiology of sex difference in depression and anxiety.Huijie LeiYasuhiro MochizukiChong ChenKosuke HagiwaraMasako HirotsuToshio MatsubaraShin NakagawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huijie Lei Yasuhiro Mochizuki Chong Chen Kosuke Hagiwara Masako Hirotsu Toshio Matsubara Shin Nakagawa Sex difference in the weighting of expected uncertainty under chronic stress
description	Abstract The neurobiological literature implicates chronic stress induced decision-making deficits as a major contributor to depression and anxiety. Given that females are twice as likely to suffer from these disorders, we hypothesized the existence of sex difference in the effects of chronic stress on decision-making. Here employing a decision-making paradigm that relies on reinforcement learning of probabilistic predictive relationships, we show female volunteers with a high level of perceived stress in the past month are more likely to make suboptimal choices than males. Computational characterizations of this sex difference suggest that while under high stress, females and males differ in their weighting but not learning of the expected uncertainty in the predictive relationships. These findings provide a mechanistic account of the sex difference in decision-making under chronic stress and may have important implications for the epidemiology of sex difference in depression and anxiety.
format	article
author	Huijie Lei Yasuhiro Mochizuki Chong Chen Kosuke Hagiwara Masako Hirotsu Toshio Matsubara Shin Nakagawa
author_facet	Huijie Lei Yasuhiro Mochizuki Chong Chen Kosuke Hagiwara Masako Hirotsu Toshio Matsubara Shin Nakagawa
author_sort	Huijie Lei
title	Sex difference in the weighting of expected uncertainty under chronic stress
title_short	Sex difference in the weighting of expected uncertainty under chronic stress
title_full	Sex difference in the weighting of expected uncertainty under chronic stress
title_fullStr	Sex difference in the weighting of expected uncertainty under chronic stress
title_full_unstemmed	Sex difference in the weighting of expected uncertainty under chronic stress
title_sort	sex difference in the weighting of expected uncertainty under chronic stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b790b6e0691144cfa610f1331b5d73b2
work_keys_str_mv	AT huijielei sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT yasuhiromochizuki sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT chongchen sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT kosukehagiwara sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT masakohirotsu sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT toshiomatsubara sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress AT shinnakagawa sexdifferenceintheweightingofexpecteduncertaintyunderchronicstress
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Sex difference in the weighting of expected uncertainty under chronic stress

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