The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabling a conformational change of the H4 N-terminal t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yasuhiro Arimura, Hiroaki Tachiwana, Hiroki Takagi, Tetsuya Hori, Hiroshi Kimura, Tatsuo Fukagawa, Hitoshi Kurumizaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b792e5547ea1411d9cc207781efaa5ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b792e5547ea1411d9cc207781efaa5ba
record_format	dspace
spelling	oai:doaj.org-article:b792e5547ea1411d9cc207781efaa5ba2021-12-02T17:01:28ZThe CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism10.1038/s41467-019-08314-x2041-1723https://doaj.org/article/b792e5547ea1411d9cc207781efaa5ba2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08314-xhttps://doaj.org/toc/2041-1723Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabling a conformational change of the H4 N-terminal tail.Yasuhiro ArimuraHiroaki TachiwanaHiroki TakagiTetsuya HoriHiroshi KimuraTatsuo FukagawaHitoshi KurumizakaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasuhiro Arimura Hiroaki Tachiwana Hiroki Takagi Tetsuya Hori Hiroshi Kimura Tatsuo Fukagawa Hitoshi Kurumizaka The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
description	Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabling a conformational change of the H4 N-terminal tail.
format	article
author	Yasuhiro Arimura Hiroaki Tachiwana Hiroki Takagi Tetsuya Hori Hiroshi Kimura Tatsuo Fukagawa Hitoshi Kurumizaka
author_facet	Yasuhiro Arimura Hiroaki Tachiwana Hiroki Takagi Tetsuya Hori Hiroshi Kimura Tatsuo Fukagawa Hitoshi Kurumizaka
author_sort	Yasuhiro Arimura
title	The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
title_short	The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
title_full	The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
title_fullStr	The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
title_full_unstemmed	The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
title_sort	cenp-a centromere targeting domain facilitates h4k20 monomethylation in the nucleosome by structural polymorphism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b792e5547ea1411d9cc207781efaa5ba
work_keys_str_mv	AT yasuhiroarimura thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hiroakitachiwana thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hirokitakagi thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT tetsuyahori thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hiroshikimura thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT tatsuofukagawa thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hitoshikurumizaka thecenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT yasuhiroarimura cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hiroakitachiwana cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hirokitakagi cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT tetsuyahori cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hiroshikimura cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT tatsuofukagawa cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism AT hitoshikurumizaka cenpacentromeretargetingdomainfacilitatesh4k20monomethylationinthenucleosomebystructuralpolymorphism
_version_	1718382170670628864

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Ejemplares similares